Key Laboratory of Chemical Biology (MOE), Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, China.
Med Res Rev. 2014 Nov;34(6):1217-41. doi: 10.1002/med.21316. Epub 2014 Apr 14.
Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide-ranging survey on the development of small-molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor-made probes for diverse types of peptidases.
肽酶可以切割无数种类底物中的特定肽键，通常在蛋白质激活、细胞信号转导和调控以及氨基酸生成用于蛋白质产生或应用于其他代谢途径中起着关键作用。它们还与许多病理状况有关，如癌症、动脉粥样硬化、关节炎和神经退行性疾病。本文综述了肽酶小分子荧光探针的发展，并实现了针对不同类型肽酶的定制探针的最新技术状态。
