• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

浦肯野细胞条纹与平行纤维-浦肯野细胞突触处的长时程抑制

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse.

作者信息

Hawkes Richard

机构信息

Department of Cell Biology and Anatomy, University of Calgary Calgary, AB, Canada ; Hotchkiss Brain Institute, University of Calgary Calgary, AB, Canada ; Genes and Development Research Group, Faculty of Medicine, University of Calgary Calgary, AB, Canada.

出版信息

Front Syst Neurosci. 2014 Mar 28;8:41. doi: 10.3389/fnsys.2014.00041. eCollection 2014.

DOI:10.3389/fnsys.2014.00041
PMID:24734006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3975104/
Abstract

The cerebellar cortex comprises a stereotyped array of transverse zones and parasagittal stripes, built around multiple Purkinje cell subtypes, which is highly conserved across birds and mammals. This architecture is revealed in the restricted expression patterns of numerous molecules, in the terminal fields of the afferent projections, in the distribution of interneurons, and in the functional organization. This review provides an overview of cerebellar architecture with an emphasis on attempts to relate molecular architecture to the expression of long-term depression (LTD) at the parallel fiber-Purkinje cell (pf-PC) synapse.

摘要

小脑皮质由围绕多种浦肯野细胞亚型构建的横向区域和矢状旁条纹的定型阵列组成，这种结构在鸟类和哺乳动物中高度保守。这种结构在众多分子的受限表达模式、传入投射的终末区域、中间神经元的分布以及功能组织中得以体现。本综述概述了小脑结构，重点是尝试将分子结构与平行纤维-浦肯野细胞（pf-PC）突触处的长时程抑制（LTD）表达联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f8/3975104/7bd744a90edc/fnsys-08-00041-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f8/3975104/9e4c8159e209/fnsys-08-00041-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f8/3975104/7bd744a90edc/fnsys-08-00041-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f8/3975104/9e4c8159e209/fnsys-08-00041-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f8/3975104/7bd744a90edc/fnsys-08-00041-g0002.jpg

相似文献

1
Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse.浦肯野细胞条纹与平行纤维-浦肯野细胞突触处的长时程抑制
Front Syst Neurosci. 2014 Mar 28;8:41. doi: 10.3389/fnsys.2014.00041. eCollection 2014.
2
Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum.小鼠小脑中浦肯野细胞亚群对磷脂酶Cβ3和Cβ4的互补性表达条带
J Comp Neurol. 2006 May 20;496(3):303-13. doi: 10.1002/cne.20912.
3
Purkinje cell subtype specification in the cerebellar cortex: early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype.小脑皮质中浦肯野细胞亚型的特异性：早期B细胞因子2可抑制zebrin II阳性浦肯野细胞表型。
Neuroscience. 2008 May 15;153(3):721-32. doi: 10.1016/j.neuroscience.2008.01.090. Epub 2008 Mar 6.
4
Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase C beta 4.通过zebrin II和磷脂酶Cβ4的表达揭示的蜂鸟（鸟纲：蜂鸟科）小脑皮质的分区
J Chem Neuroanat. 2009 Jan;37(1):55-63. doi: 10.1016/j.jchemneu.2008.10.001. Epub 2008 Oct 18.
5
Purkinje cell compartmentation of the cerebellum of microchiropteran bats.小型食虫蝙蝠小脑的浦肯野细胞分区
J Comp Neurol. 2009 Nov 10;517(2):193-209. doi: 10.1002/cne.22147.
6
Purkinje cell compartmentation as revealed by zebrin II expression in the cerebellar cortex of pigeons (Columba livia).斑带蛋白II在鸽子（家鸽）小脑皮质中的表达揭示的浦肯野细胞分区
J Comp Neurol. 2007 Apr 1;501(4):619-30. doi: 10.1002/cne.21266.
7
Phospholipase Cbeta4 expression reveals the continuity of cerebellar topography through development.磷脂酶Cβ4的表达揭示了小脑拓扑结构在发育过程中的连续性。
J Comp Neurol. 2007 Jun 10;502(5):857-71. doi: 10.1002/cne.21352.
8
Antigenic compartmentation of the primate and tree shrew cerebellum: a common topography of zebrin II in Macaca mulatta and Tupaia belangeri.灵长类动物和树鼩小脑的抗原分区：猕猴和笔尾树鼩中zebrin II的共同拓扑结构。
J Anat. 2004 Apr;204(4):257-69. doi: 10.1111/j.0021-8782.2004.00282.x.
9
Antigenic compartmentation of the cat cerebellar cortex.猫小脑皮质的抗原分隔
Brain Res. 2003 Jul 4;977(1):1-15. doi: 10.1016/s0006-8993(03)02569-1.
10
Antigenic compartmentation of the cerebellar cortex in the syrian hamster Mesocricetus auratus.叙利亚仓鼠（金仓鼠）小脑皮质的抗原分区
Brain Res. 2003 Jun 6;974(1-2):176-83. doi: 10.1016/s0006-8993(03)02576-9.

引用本文的文献

1
ARSACS: Clinical Features, Pathophysiology and iPS-Derived Models.遗传性痉挛性共济失调（ARSACS）：临床特征、病理生理学及诱导多能干细胞衍生模型
Cerebellum. 2025 Jan 3;24(1):24. doi: 10.1007/s12311-024-01777-9.
2
PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum.蛋白酪氨酸磷酸酶δ（PTPδ）是发育中小脑内形成和维持攀缘纤维至浦肯野细胞突触的突触前组织者。
Front Mol Neurosci. 2023 Jun 22;16:1206245. doi: 10.3389/fnmol.2023.1206245. eCollection 2023.
3
Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings.

本文引用的文献

1
Long-term potentiation of inhibitory synaptic transmission onto cerebellar Purkinje neurons contributes to adaptation of vestibulo-ocular reflex.小脑浦肯野神经元抑制性突触传递的长时程增强有助于前庭眼反射的适应。
J Neurosci. 2013 Oct 23;33(43):17209-20. doi: 10.1523/JNEUROSCI.0793-13.2013.
2
Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.十四烷酰佛波醇 12-乙酸酯通过激活蛋白激酶 Cδ 和 ε 增强海马体的长时程增强。
Korean J Physiol Pharmacol. 2013 Feb;17(1):51-6. doi: 10.4196/kjpp.2013.17.1.51. Epub 2013 Feb 14.
3
The compartmental restriction of cerebellar interneurons.
高密度多电极阵列记录揭示小脑回路中信号传播的各向异性和频率依赖性
Biomedicines. 2023 May 18;11(5):1475. doi: 10.3390/biomedicines11051475.
4
Hypothermia increases cold-inducible protein expression and improves cerebellar-dependent learning after hypoxia ischemia in the neonatal rat.低温增加冷诱导蛋白表达，并改善缺氧缺血后新生大鼠小脑依赖的学习能力。
Pediatr Res. 2023 Aug;94(2):539-546. doi: 10.1038/s41390-023-02535-z. Epub 2023 Feb 21.
5
Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones.小脑浦肯野细胞内在可塑性的异质性与皮质分子区域相关。
iScience. 2021 Dec 28;25(1):103705. doi: 10.1016/j.isci.2021.103705. eCollection 2022 Jan 21.
6
Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice.分子特性与位置对夏尔沃-萨格奈常染色体隐性遗传性痉挛性共济失调小鼠浦肯野细胞易损性的影响。
Front Cell Neurosci. 2021 Dec 14;15:707857. doi: 10.3389/fncel.2021.707857. eCollection 2021.
7
SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2.SCA7 小鼠小脑病理学显示关键浦肯野细胞特征基因优先下调，并与 SCA1 和 SCA2 具有共同的疾病特征。
J Neurosci. 2021 Jun 2;41(22):4910-4936. doi: 10.1523/JNEUROSCI.1882-20.2021. Epub 2021 Apr 22.
8
The Cerebellar Nuclei and Dexterous Limb Movements.小脑核与灵巧肢体运动。
Neuroscience. 2020 Dec 1;450:168-183. doi: 10.1016/j.neuroscience.2020.06.046. Epub 2020 Jul 9.
9
Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits.浦肯野细胞与颗粒细胞的相互作用协调功能性小脑回路的发育。
Neuroscience. 2021 May 10;462:4-21. doi: 10.1016/j.neuroscience.2020.06.010. Epub 2020 Jun 14.
10
The Relationship Between Zebrin Expression and Cerebellar Functions: Insights From Neuroimaging Studies.斑马蛋白表达与小脑功能的关系：神经影像学研究的见解
Front Neurol. 2020 Apr 22;11:315. doi: 10.3389/fneur.2020.00315. eCollection 2020.
小脑中间神经元的隔室限制。
Front Neural Circuits. 2013 Jan 22;6:123. doi: 10.3389/fncir.2012.00123. eCollection 2012.
4
Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons.谷氨酸受体 δ2 与代谢型谷氨酸受体 1（mGluR1）、蛋白激酶 Cγ 和经典瞬时受体电位 3 相关联，并调节小脑浦肯野神经元中 mGluR1 介导的突触传递。
J Neurosci. 2012 Oct 31;32(44):15296-308. doi: 10.1523/JNEUROSCI.0705-12.2012.
5
Zebrin-immunopositive and -immunonegative stripe pairs represent functional units in the pigeon vestibulocerebellum.斑马纹阳性和阴性条纹对代表鸽子前庭小脑的功能单位。
J Neurosci. 2012 Sep 12;32(37):12769-79. doi: 10.1523/JNEUROSCI.0197-12.2012.
6
Distributed synergistic plasticity and cerebellar learning.分布式协同可塑性与小脑学习。
Nat Rev Neurosci. 2012 Sep;13(9):619-35. doi: 10.1038/nrn3312. Epub 2012 Aug 16.
7
Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity.小脑皮层的旁矢状区在兴奋性、信息处理和突触可塑性方面存在差异。
Cerebellum. 2012 Jun;11(2):418-9. doi: 10.1007/s12311-011-0347-1.
8
Calcium as a trigger for cerebellar long-term synaptic depression.钙作为小脑长时程突触抑制的触发因素。
Cerebellum. 2012 Sep;11(3):706-17. doi: 10.1007/s12311-011-0314-x.
9
Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice.PEP-19/PCP4 基因敲除小鼠运动学习能力受损和小脑突触可塑性改变。
Mol Cell Biol. 2011 Jul;31(14):2838-44. doi: 10.1128/MCB.05208-11. Epub 2011 May 16.
10
Reevaluating the role of LTD in cerebellar motor learning.重新评估 LTD 在小脑运动学习中的作用。
Neuron. 2011 Apr 14;70(1):43-50. doi: 10.1016/j.neuron.2011.02.044.