Department of Neurology and Stroke Center, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
Department of Radiology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
Evid Based Complement Alternat Med. 2014;2014:765413. doi: 10.1155/2014/765413. Epub 2014 Mar 5.
Abundant evidence from previous fMRI studies on acupuncture has revealed significant modulatory effects at widespread brain regions. However, few reports on the modulation to the default mode network (DMN) of stroke patients have been investigated in the field of acupuncture. To study the modulatory effects of acupuncture on the DMN of stroke patients, eight right hemispheric infarction and stable ischemic stroke patients and ten healthy subjects were recruited to undergo resting state fMRI scanning before and after acupuncture stimulation. Functional connectivity analysis was applied with the bilateral posterior cingulate cortices chosen as the seed regions. The main finding demonstrated that the interregional interactions between the ACC and PCC especially enhanced after acupuncture at GB34 in stroke patients, compared with healthy controls. The results indicated that the possible mechanisms of the modulatory effects of acupuncture on the DMN of stroke patients could be interpreted in terms of cognitive ability and motor function recovery.
大量先前的 fMRI 研究证据表明，针刺在广泛的脑区具有显著的调节作用。然而，在针刺领域，针对中风患者的默认模式网络（DMN）的调节作用的研究报告较少。为了研究针刺对中风患者 DMN 的调节作用，招募了 8 名右侧半球梗死和稳定型缺血性中风患者以及 10 名健康受试者，在针刺刺激前后进行静息态 fMRI 扫描。使用双侧后扣带回皮质作为种子区域进行功能连接分析。主要发现表明，与健康对照组相比，针刺 GB34 后中风患者的 ACC 和 PCC 之间的区域间相互作用明显增强。结果表明，针刺对中风患者 DMN 的调节作用的可能机制可以从认知能力和运动功能恢复的角度来解释。
