Zargar Bilal A, Masoodi Mubashir H, Ahmed Bahar, Ganie Showkat A
Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi 110062, India.
ISRN Pharmacol. 2014 Mar 10;2014:182362. doi: 10.1155/2014/182362. eCollection 2014.
The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively examined for its in vitro antioxidant activity, and the preliminary phytochemical screening was carried out using standard protocols. Male Wistar rats were induced with hyperlipidemia using high-fat diet and were treated orally with hydroalcoholic and aqueous extracts at the dose of 200 mg/kg bw for 30 days. TGs, TC, LDL-c, and AI were significantly reduced while HDL-c, SOD, and GPx levels rose to a considerable extent. After subjecting to acute toxicity testing, the extracts were found to be safe. The observations suggest antihyperlipidemic and antioxidant potential of P. emodi in high-fat diet induced hyperlipidemic/oxidative stressed rats.
本研究旨在评估藏药高山芍药根茎提取物对血清甘油三酯（TGs）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）、动脉粥样硬化指数（AI）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的影响。对该植物进行了广泛的体外抗氧化活性检测，并采用标准方法进行了初步的植物化学筛选。采用高脂饮食诱导雄性Wistar大鼠发生高脂血症，并以200mg/kg体重的剂量口服给予水醇提取物和水提取物，持续30天。TGs、TC、LDL-c和AI显著降低，而HDL-c、SOD和GPx水平则显著升高。经过急性毒性试验，发现提取物是安全的。这些观察结果表明，高山芍药在高脂饮食诱导的高脂血症/氧化应激大鼠中具有抗高脂血症和抗氧化潜力。
