Vrbikova Jana, Hill Martin, Fanta Michael
Institute of Endocrinology , Prague , Czech Republic and.
Gynecol Endocrinol. 2014 Sep;30(9):664-6. doi: 10.3109/09513590.2014.912265. Epub 2014 Apr 15.
We evaluated the utility of impaired fasting plasma glucose as defined by ADA to identify women with polycystic ovary syndrome (PCOS) affected by impaired glucose metabolism (i.e. impaired fasting glucose, impaired glucose tolerance and diabetes mellitus). In 330 women with PCOS, according to ESHRE criteria, an oral glucose tolerance test was done. Impaired fasting glucose was present in 36 women (12%), impaired glucose tolerance in 29 women (8.8%) and diabetes mellitus in 10 women (3%), 4 of them have fasting glucose higher than 7 mmol/l. The combination of impaired fasting glucose and impaired glucose tolerance was seen in 5 women (1.5%). The sensitivity of impaired fasting glucose for the detection of impaired glucose tolerance was 24% and specificity 91.8%. When fasting glucose above 5.6 mmol/l was used as the screening criterion, 28/35 subjects (80%) would have been missed. We conclude that fasting plasma glucose is not sufficiently sensitive for the detection of impaired glucose tolerance and diabetes mellitus type 2 in women with PCOS.
我们评估了美国糖尿病协会（ADA）定义的空腹血糖受损在识别受糖代谢受损影响的多囊卵巢综合征（PCOS）女性（即空腹血糖受损、糖耐量受损和糖尿病）方面的效用。根据欧洲人类生殖与胚胎学会（ESHRE）标准，对330名PCOS女性进行了口服葡萄糖耐量试验。36名女性（12%）存在空腹血糖受损，29名女性（8.8%）存在糖耐量受损，10名女性（3%）患有糖尿病，其中4人空腹血糖高于7 mmol/L。5名女性（1.5%）同时存在空腹血糖受损和糖耐量受损。空腹血糖受损检测糖耐量受损的敏感性为24%，特异性为91.8%。当以空腹血糖高于5.6 mmol/L作为筛查标准时，28/35的受试者（80%）将会被漏诊。我们得出结论，空腹血糖对检测PCOS女性的糖耐量受损和2型糖尿病的敏感性不足。
