Wang Jun-Feng, Xu Fu-Quan, Wang Zhen, Lu Xin, Wan Jun-Ting, Yang Bin, Zhou Xue-Feng, Zhang Tian-Yu, Tu Zheng-Chao, Liu Yonghong
a CAS Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
Nat Prod Res. 2014;28(14):1070-4. doi: 10.1080/14786419.2014.905935. Epub 2014 Apr 16.
One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 μM.
从海绵来源的真菌节菱孢菌ZSDS1-F3中分离出一种新的萘衍生物1,8-二羟基萘酚-1-O-α-L-鼠李糖苷（1）、一种已知的α-二苯并吡喃酮交链孢酚（2）和五种呫吨酮（3-7）。所有分离得到的化合物（1-7）均通过光谱数据的综合分析确定，尤其是一维和二维核磁共振（HMQC和HMBC）光谱。在初步生物活性测试中，化合物3表现出中等程度的COX-2抑制活性，IC50值为12.2 μM。
