一种海洋来源真菌， 分离得到的新查尔酮及其生物活性。
New Chromones from a Marine-Derived Fungus, sp., and Their Biological Activity.
机构信息
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, 99 South Road of Longkun Road, Haikou 571158, China.
出版信息
Molecules. 2018 Aug 9;23(8):1982. doi: 10.3390/molecules23081982.
Five new chromone derivatives, arthones A⁻E (⁻), together with eight known biogenetically related cometabolites (⁻), were isolated from a deep-sea-derived fungus sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of and were established by electronic circular dichroism (ECD) calculations and that of was determined by modified Mosher ester method. Compounds and exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.
从深海来源真菌 sp. UJNMF0008 中分离得到了五个新的色酮衍生物 Arthones A⁻E（⁻），以及八个已知的生物相关共代谢产物（⁻）。通过详细的光谱数据分析确定了它们的结构，而 和 的绝对构型则通过电子圆二色性（ECD）计算确定， 的绝对构型则通过改进的 Mosher 酯法确定。化合物 和 具有很强的抗氧化活性，对 DPPH 和 ABTS 自由基有清除作用，IC 值范围为 16.9 至 18.7 μM。同时，在 50.0 μM 的浓度下，没有化合物在我们的抗菌和抗炎测定中表现出明显的生物活性。
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