Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 4146, Bethesda, MD 20892, USA; Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany.
Laboratory of Experimental Carcinogenesis (LEC), Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 4146, Bethesda, MD 20892, USA.
Cancer Cell. 2014 Apr 14;25(4):409-11. doi: 10.1016/j.ccr.2014.03.032.
Hepatocellular adenomas (HCAs) are clinically relevant benign liver lesions that commonly occur in women on hormonal contraceptives. In this issue of Cancer Cell, Pilati and colleagues present an integrative multi-"omics"-based analysis of HCA and identify recurrent genetic alterations associated with adenoma-carcinoma transition and new drugable targets.
肝细胞腺瘤（HCA）是临床上有意义的良性肝病变，常见于使用激素避孕药的女性。在本期《癌细胞》杂志中，Pilati 及其同事对 HCA 进行了基于整合多组学的分析，鉴定出与腺瘤-癌转化相关的复发性遗传改变和新的可用药靶标。
