轻度和中度阿尔茨海默病患者大型随机临床试验中依赖量表的心理测量特性。
Psychometric properties of the Dependence Scale in large randomized clinical trials of patients with mild and moderate Alzheimer's disease.
作者信息
Wyrwich Kathleen W, Auguste Priscilla, Buchanan Jacqui, Rudell Katja, Lacey Loretto, Leibman Christopher, Symonds Tara, Brashear H Robert
机构信息
Evidera (formerly United BioSource Corporation), Bethesda, MD, USA
Evidera (formerly United BioSource Corporation), Bethesda, MD, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2014 Nov;29(7):620-9. doi: 10.1177/1533317514527336. Epub 2014 Apr 15.
OBJECTIVE
The need for assistance from others is a hallmark concern in Alzheimer's disease (AD). The psychometric properties of the Dependence Scale (DS) for measuring treatment benefit were investigated in large randomized clinical trials of patients with mild to moderate AD.
METHODS
Reliability, validity, and responsiveness of the DS were examined. Path models appraised relationships and distinctiveness of key AD measures. The responder definition was empirically derived.
RESULTS
Generally acceptable reliability (α ≥ .65), significant (P < .001) known-groups tests, and moderate to strong correlations (r ≥ .31) confirmed the DS psychometric properties. Path models supported relationships and distinctiveness of key AD measures. A DS change of ≤ 1 point for patients with limited home care and ≤ 2 points for patients with assisted living care best described stability of the level of dependence on caregivers.
CONCLUSION
The DS is a psychometrically robust measure in mild to moderate AD. The empirically derived responder definition aids in the interpretation of DS change.
目的
对他人帮助的需求是阿尔茨海默病（AD）的一个标志性问题。在轻度至中度AD患者的大型随机临床试验中，对用于衡量治疗益处的依赖量表（DS）的心理测量特性进行了研究。
方法
检查了DS的信度、效度和反应性。路径模型评估了关键AD测量指标之间的关系和独特性。反应者定义是通过实证得出的。
结果
总体可接受的信度（α≥0.65）、显著的（P<0.001）已知组检验以及中度至强的相关性（r≥0.31）证实了DS的心理测量特性。路径模型支持关键AD测量指标之间的关系和独特性。对于家庭护理有限的患者，DS变化≤1分，对于辅助生活护理的患者，DS变化≤2分，最能描述对照顾者依赖程度的稳定性。
结论
DS在轻度至中度AD中是一种心理测量稳健的测量方法。通过实证得出的反应者定义有助于对DS变化的解释。
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