轻度至中度阿尔茨海默病依赖性量表的信度、效度及解读。
Reliability, validity, and interpretation of the dependence scale in mild to moderately severe Alzheimer's disease.
机构信息
1Evidera, Bethesda, MD, USA, formerly a division of United BioSource Corporation, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2013 Dec;28(8):738-49. doi: 10.1177/1533317513504609.
INTRODUCTION
The Dependence Scale (DS) was designed to measure dependence on others among patients with Alzheimer's disease (AD). The objectives of this research were primarily to strengthen the psychometric evidence for the use of the DS in AD studies.
METHODS
Patients with mild to moderately severe AD were examined in 3 study databases. Within each data set, internal consistency, validity, and responsiveness were examined, and structural equation models were fit.
RESULTS
The DS has strong psychometric properties. The DS scores differed significantly across known groups and demonstrated moderate to strong correlations with measures hypothesized to be related to dependence (|r| ≥ .31). Structural equation modeling supported the validity of the DS concept. An anchor-based DS responder definition to interpret a treatment benefit over time was identified.
DISCUSSION
The DS is a reliable, valid, and interpretable measure of dependence associated with AD and is shown to be related to--but provides information distinct from--cognition, functioning, and behavior.
简介
依赖量表（DS）旨在衡量阿尔茨海默病（AD）患者对他人的依赖程度。本研究的主要目的是为 DS 在 AD 研究中的应用提供更强的心理测量学证据。
方法
在 3 个研究数据库中对轻度至中度严重 AD 患者进行了检查。在每个数据集内，均检验了内部一致性、有效性和反应性，并拟合了结构方程模型。
结果
DS 具有很强的心理测量学特性。DS 评分在已知组间有显著差异，并与假设与依赖相关的测量方法（|r|≥.31）呈中度至强相关性。结构方程模型支持 DS 概念的有效性。确定了一个基于锚点的 DS 应答者定义，用于随时间解释治疗益处。
讨论
DS 是一种与 AD 相关的可靠、有效和可解释的依赖测量工具，与认知、功能和行为相关（但提供的信息与之不同）。
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