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本文引用的文献

1
Quality of Life and Utility Measurement in a Large Clinical Trial Sample of Patients with Mild to Moderate Alzheimer's Disease: Determinants and Level of Changes Observed.轻度至中度阿尔茨海默病患者大型临床试验样本中的生活质量与效用测量：观察到的决定因素及变化水平
Value Health. 2015 Jul;18(5):638-45. doi: 10.1016/j.jval.2015.03.1787. Epub 2015 Apr 10.
2
Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden: the DADE study.阿尔茨海默病的依赖与服务利用成本、生活质量和照护者负担：DADE 研究。
Alzheimers Dement. 2015 Mar;11(3):280-90. doi: 10.1016/j.jalz.2014.03.001. Epub 2014 Jul 26.
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Introduction to mediation analysis with structural equation modeling.结构方程模型的中介效应分析简介
Shanghai Arch Psychiatry. 2013 Dec;25(6):390-4. doi: 10.3969/j.issn.1002-0829.2013.06.009.
4
Psychometric properties of the Dependence Scale in large randomized clinical trials of patients with mild and moderate Alzheimer's disease.轻度和中度阿尔茨海默病患者大型随机临床试验中依赖量表的心理测量特性。
Am J Alzheimers Dis Other Demen. 2014 Nov;29(7):620-9. doi: 10.1177/1533317514527336. Epub 2014 Apr 15.
5
Reliability, validity, and interpretation of the dependence scale in mild to moderately severe Alzheimer's disease.轻度至中度阿尔茨海默病依赖性量表的信度、效度及解读。
Am J Alzheimers Dis Other Demen. 2013 Dec;28(8):738-49. doi: 10.1177/1533317513504609.
6
The validity of dependence as a health outcome measure in Alzheimer's disease.依赖作为阿尔茨海默病健康结局测量指标的有效性。
Am J Alzheimers Dis Other Demen. 2013 May;28(3):245-52. doi: 10.1177/1533317513481092. Epub 2013 Mar 19.
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2013 Alzheimer's disease facts and figures.2013 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2013 Mar;9(2):208-45. doi: 10.1016/j.jalz.2013.02.003.
8
Health-related quality-of-life instruments for Alzheimer's disease and mixed dementia.用于阿尔茨海默病和混合性痴呆的与健康相关的生活质量工具。
Int Psychogeriatr. 2013 May;25(5):691-706. doi: 10.1017/S1041610212002293. Epub 2013 Jan 25.
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The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model.多奈哌齐、加兰他敏、利伐斯的明和美金刚治疗阿尔茨海默病的有效性和成本效果（技术评估第 111 号回顾）：系统评价和经济模型。
Health Technol Assess. 2012;16(21):1-470. doi: 10.3310/hta16210.
10
Predictors of family caregiver ratings of patient quality of life in Alzheimer disease: cross-sectional results from the Canadian Alzheimer's Disease Quality of Life Study.阿尔茨海默病患者生活质量的家庭照料者评分预测因素：来自加拿大阿尔茨海默病生活质量研究的横断面结果。
Am J Geriatr Psychiatry. 2011 Oct;19(10):891-901. doi: 10.1097/JGP.0b013e3182006a7f.

阿尔茨海默病中依赖与生活质量的路径分析

A Path Analysis of Dependence and Quality of Life in Alzheimer's Disease.

作者信息

Garre-Olmo Josep, Vilalta-Franch Joan, Calvó-Perxas Laia, López-Pousa Secundino

机构信息

1 Girona Biomedical Research Institute (IDIBGI), Girona, Spain.

2 Institut d'Assistència Sanitària, Girona, Spain.

出版信息

Am J Alzheimers Dis Other Demen. 2017 Mar;32(2):108-115. doi: 10.1177/1533317516688297. Epub 2017 Jan 22.

DOI:10.1177/1533317516688297
PMID:28110545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10852779/
Abstract

OBJECTIVE

To determine the direct and indirect relationships of cognitive, functional, and behavioral factors and other medical comorbidities with the quality of life (QoL) of patients with Alzheimer's disease (AD) according to the theoretical model of dependence.

METHODS

Observational and cross-sectional study. Cognitive and functional status, behavior, dependence, medical comorbidities, and QoL were assessed by using standardized instruments. A path analysis was used to model the direct and indirect relationships among clinical indicators according to the theoretically based model of dependence.

RESULTS

The sample consisted of 343 patients with AD (32.1% mild, 36.7% moderate, and 31.2% severe). Medical comorbidities, disease severity, and dependence level had a direct relationship with QoL. The functional disability and the behavior disturbances were indirectly related to QoL via dependence level, and the cognitive impairment was indirectly related to QoL via severity level.

CONCLUSION

Direct and indirect effects exist between clinical indicators, dependence, and QoL.

摘要

目的

根据依赖理论模型，确定认知、功能和行为因素以及其他医学合并症与阿尔茨海默病（AD）患者生活质量（QoL）之间的直接和间接关系。

方法

观察性横断面研究。使用标准化工具评估认知和功能状态、行为、依赖程度、医学合并症和生活质量。根据基于理论的依赖模型，采用路径分析对临床指标之间的直接和间接关系进行建模。

结果

样本包括343例AD患者（轻度32.1%，中度36.7%，重度31.2%）。医学合并症、疾病严重程度和依赖程度与生活质量有直接关系。功能残疾和行为障碍通过依赖程度与生活质量间接相关，认知障碍通过严重程度与生活质量间接相关。

结论

临床指标、依赖程度和生活质量之间存在直接和间接影响。