Department of Obstetrics and Gynecology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
World J Surg Oncol. 2013 Nov 20;11:297. doi: 10.1186/1477-7819-11-297.
Astrocyte elevated gene-1(AEG-1) plays an important role in the development and progression of certain types of human cancers. However, the expression dynamics of AEG-1 in cervical cancer and its clinical/prognostic significance are unclear.
In present study, the methods of tissue microarrays (TMA) and immunohistochemistry (IHC) were utilized to investigate AEG-1 expression in cervical intraepithelial neoplasia (CIN) and cervical cancer. Receiver operating characteristic (ROC) curve analysis, χ2 test, Kaplan-Meier plots, and multivariate Cox regression analysis were used to analyze the data.
The expression level of AEG-1 was increased from CIN I to CIN III. High expression of AEG-1 could be observed in 61.1% (55/90) of cervical cancer. Moreover, high expression of AEG-1 correlated with tumor size and lymph node metastasis (all P <0.05). More importantly, high expression of AEG-1 was closely associated with cervical cancer patient shortened survival time as evidenced by univariate and multivariate analysis (P <0.05).
Our data suggest for the first time that high expression of AEG-1 is associated significantly with progression of cervical cancer. AEG-1 overexpression, as examined by IHC, has the potential to be used as an immunomarker to predict prognosis of cervical cancer patients.
星形细胞上调基因-1（AEG-1）在某些类型的人类癌症的发展和进展中发挥着重要作用。然而，AEG-1 在宫颈癌中的表达动态及其临床/预后意义尚不清楚。
本研究采用组织微阵列（TMA）和免疫组织化学（IHC）方法检测宫颈上皮内瘤变（CIN）和宫颈癌中 AEG-1 的表达。采用受试者工作特征（ROC）曲线分析、χ2 检验、Kaplan-Meier 图和多因素 Cox 回归分析进行数据分析。
AEG-1 的表达水平从 CIN I 增加到 CIN III。在 90 例宫颈癌中，有 61.1%（55/90）观察到 AEG-1 的高表达。此外，AEG-1 的高表达与肿瘤大小和淋巴结转移相关（均 P<0.05）。更重要的是，通过单因素和多因素分析，AEG-1 的高表达与宫颈癌患者的生存时间缩短密切相关（P<0.05）。
我们的数据首次表明，AEG-1 的高表达与宫颈癌的进展显著相关。通过 IHC 检测到的 AEG-1 过表达有可能被用作预测宫颈癌患者预后的免疫标志物。
