Cardiff School of Healthcare Sciences, Cardiff University, Cardiff, Wales, UK,
J Cachexia Sarcopenia Muscle. 2014 Jun;5(2):89-94. doi: 10.1007/s13539-014-0142-1. Epub 2014 Apr 16.
Cancer cachexia has impact on patients and their family members. Patients experience loss of weight often accompanied by anorexia and other debilitating symptoms that have clinical impact and impact everyday life. The importance of understanding this impact lies in (1) the alleviation of cachexia-related suffering and (2) its implications for treating cachexia.
Two decades of exploratory investigation of the manifestations, meaning and management of cancer cachexia reveal emotional and social impacts for both patients and their carers. Patients can describe change in appearance and loss of physical strength often accompanied by change in eating habits (amount, type and pattern of food intake). The psychosocial effects can include loss of independence, sense of failure, sense of helplessness, conflict with family members over food, social isolation and thoughts of death. They are effects that can distress. Conversely, weight loss, especially early in its course and for those who are obese, can be perceived as beneficial, which inhibits self-management of diet and physical activity.
Models of the psychosocial effects of cancer cachexia have been developed, leading to, as yet unproven, propositions of how negative patient and family impacts can be addressed. This literature overlooks the potential importance of psychosocial intervention to emerging multimodal treatments for the multicausal syndrome. Psychosocial intervention in cachexia should be tested for potential to help people affected by cancer cachexia feel better but also for potential to make people better by aiding uptake and compliance with multimodal therapy.
癌症恶病质会对患者及其家属产生影响。患者常经历体重减轻,同时伴有厌食和其他使身体虚弱的症状,这些症状对日常生活有临床影响。了解这种影响的重要性在于:(1) 减轻恶病质相关的痛苦,(2) 了解其对恶病质治疗的影响。
对癌症恶病质的表现、意义和管理进行了二十多年的探索性研究,揭示了患者及其照顾者的情绪和社会影响。患者可以描述外观改变和体力下降,常伴有饮食习惯改变(进食量、种类和模式)。心理社会影响包括丧失独立性、失败感、无助感、与家人在食物问题上的冲突、社会孤立和死亡念头。这些影响可能会造成困扰。相反,体重减轻,尤其是在病程早期和肥胖患者中,可能被视为有益的,这会抑制对饮食和身体活动的自我管理。
已经开发出癌症恶病质心理社会影响的模型,从而提出了如何解决患者和家属负面影响的未经验证的假设。该文献忽视了心理社会干预对新兴多模式治疗多种病因综合征的潜在重要性。应该对恶病质的心理社会干预进行测试,以评估其帮助癌症恶病质患者改善身体状况的潜力,同时评估其通过辅助多模式治疗的接受和依从性来改善患者状况的潜力。