Phan Liem Minh, Yeung Sai-Ching Jim, Lee Mong-Hong
1 Department of Molecular and Cellular Oncology, 2 Department of General Internal Medicine, Ambulatory Treatment and Emergency Care, 3 Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, TX77030, USA.
Cancer Biol Med. 2014 Mar;11(1):1-19. doi: 10.7497/j.issn.2095-3941.2014.01.001.
Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
癌细胞重新连接其代谢和能量产生网络以支持并实现快速增殖、持续生长、在恶劣条件下存活、侵袭、转移以及对癌症治疗产生抗性，这一点已有充分记录。自奥托·瓦尔堡博士于1930年发现癌细胞代谢改变以来，数千项研究揭示了癌症代谢的各个方面，其共同目标是通过靶向癌细胞的能量代谢找到有效消除肿瘤细胞的新方法。本综述强调了癌症代谢主要特征的重要性，总结了该领域近期的显著进展，并指出了将这些科学发现转化为挽救生命的诊断和治疗方法以帮助癌症患者的潜力。
