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蛹虫草提取物对饮食-链脲佐菌素诱导的糖尿病斯普拉格-道利大鼠的抗糖尿病活性研究。

Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats.

作者信息

Dong Yuan, Jing Tianjiao, Meng Qingfan, Liu Chungang, Hu Shuang, Ma Yihang, Liu Yan, Lu Jiahui, Cheng Yingkun, Wang Di, Teng Lirong

机构信息

College of Life Science, Jilin University, Changchun 130012, China.

College of Clinical Medicine, Jilin University, Changchun 130012, China.

出版信息

Biomed Res Int. 2014;2014:160980. doi: 10.1155/2014/160980. Epub 2014 Mar 11.

DOI:10.1155/2014/160980
PMID:24738047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3967809/
Abstract

Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities of Cordyceps militaris on diet-streptozotocin-induced type 2 diabetes mellitus in rats. Diabetic rats were orally administered with water extract or alcohol extract at 0.05 g/kg and 2 g/kg for 3 weeks, and then, the factors levels related to blood glucose, lipid, free radicals, and even nephropathy were determined. Pathological alterations on liver and kidney were examined. Data showed that, similar to metformin, Cordyceps militaris extracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum. Cordyceps militaris extracts exhibit antioxidative effects indicated by normalized superoxide dismutase and glutathione peroxidase levels. The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection of Cordyceps militaris extracts against diabetic nephropathy, which was confirmed by pathological morphology reversion. Collectively, Cordyceps militaris extract, a safe pharmaceutical agent, presents excellent antidiabetic and antinephropathic activities and thus has great potential as a new source for diabetes treatment.

摘要

由于糖尿病的高发病率和高并发症，它被视为世界上的第三大“杀手”。因此，从草药或真菌中寻找替代抗糖尿病药物的需求非常迫切。我们目前的研究旨在调查蛹虫草对饮食-链脲佐菌素诱导的大鼠2型糖尿病的抗糖尿病活性。将糖尿病大鼠分别以0.05 g/kg和2 g/kg的剂量口服给予水提取物或醇提取物，持续3周，然后测定与血糖、血脂、自由基甚至肾病相关的因子水平。检查肝脏和肾脏的病理改变。数据显示，与二甲双胍类似，蛹虫草提取物通过促进葡萄糖代谢显著降低血糖水平，并强烈抑制血清中的总胆固醇和甘油三酯浓度。蛹虫草提取物表现出抗氧化作用，超氧化物歧化酶和谷胱甘肽过氧化物酶水平恢复正常表明了这一点。对血尿素氮、肌酐、尿酸和蛋白质的抑制作用表明蛹虫草提取物对糖尿病肾病具有保护作用，病理形态学的恢复证实了这一点。总的来说，蛹虫草提取物是一种安全的药剂，具有出色的抗糖尿病和抗肾病活性，因此作为糖尿病治疗的新来源具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c912/3967809/358e403f8060/BMRI2014-160980.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c912/3967809/358e403f8060/BMRI2014-160980.008.jpg

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