蛹虫草对人脐静脉内皮细胞高糖诱导氧化应激的保护作用。
Protective effect of Cordyceps militaris against high glucose-induced oxidative stress in human umbilical vein endothelial cells.
机构信息
Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District, Tainan, Taiwan, ROC.
Department of Biotechnology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te District, Tainan, Taiwan, ROC.
出版信息
Food Chem. 2011 Dec 1;129(3):871-6. doi: 10.1016/j.foodchem.2011.05.037. Epub 2011 May 11.
The protective effect of Cordyceps militaris against high glucose-induced oxidative stress in human umbilical vein endothelial cells (HUVECs), as compared with Cordyceps sinensis, was examined. The cytotoxicity of HUVECs induced by 40mM glucose was ameliorated by water extracts of C. militaris (CME) and water extracts of C. sinensis (CSE). CME and CSE inhibited the increase in ROS and NO in HUVECs induced by 40mM high glucose. Moreover, CME increased the Bcl-2/Bax ratio, modulated the mitochondrial membrane potential and reduced the caspase-3 activity in high glucose-induced HUVECs. In addition, cordycepin, a component of CME and CSE, displayed protective effects against oxidative stress, which was partly responsible for the cytoprotective effects of CME and CSE against high glucose-induced oxidative stress in HUVECs. Overall, the obtained results show C. militaris helps preventing diabetic endothelial dysfunction and related complications.
比较蛹虫草（Cordyceps militaris）和冬虫夏草（Cordyceps sinensis）对人脐静脉内皮细胞（HUVECs）在高葡萄糖诱导的氧化应激中的保护作用。40mM 葡萄糖诱导的 HUVECs 细胞毒性可被蛹虫草水提取物（CME）和冬虫夏草水提取物（CSE）减轻。CME 和 CSE 抑制了 40mM 高葡萄糖诱导的 HUVECs 中 ROS 和 NO 的增加。此外，CME 增加了高葡萄糖诱导的 HUVECs 中的 Bcl-2/Bax 比值，调节了线粒体膜电位，并降低了 caspase-3 活性。此外，CME 和 CSE 的成分虫草素对氧化应激具有保护作用，这部分解释了 CME 和 CSE 对 HUVECs 高葡萄糖诱导的氧化应激的细胞保护作用。总的来说，这些结果表明蛹虫草有助于预防糖尿病内皮功能障碍和相关并发症。
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