Milčić Danijela, Janković Slavenka, Vesić Sonja, Milinković Mirjana, Janković Janko
Institute of Dermatovenereology, Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Int J Dermatol. 2015;54(5):523-8. doi: 10.1111/ijd.12391. Epub 2014 Apr 16.
Psoriasis has a substantial impact on patients' quality of life.
The aims of this study were to assess the impact of the clinical severity of psoriasis on patients' quality of life and to determine the effects of psoriasis-related stress on patients' everyday life.
The cross-sectional study was conducted at the Institute of Dermatovenereology, Clinical Center of Serbia, Belgrade. The study included 201 patients (124 men and 77 women), aged 18-70 with a diagnosis of psoriasis, hospitalized or treated as outpatients during 2009. For the assessment of patients' quality of life, the psoriasis disability index (PDI) was used. The stress related to psoriasis was measured with the psoriasis life stress inventory (PLSI) and disease severity with the psoriasis area and severity index (PASI).
We found moderate correlation between PLSI and all PDI subscales and overall score (correlation coefficients ranged from 0.334 to 0.521). The correlation between PASI and PDI subscales was weak, while we failed to find any significant correlation between PASI and the PLSI. The results of multiple regression analysis indicated that stress, more severe disease, and lower educational level are significant determining factors of a poorer quality of life in patients with psoriasis.
Our results support the importance of assessing the quality of life in psoriasis and effects of stress in patients' adjustment to their condition and may have important implications for a psychological stress management approach in the clinical management of psoriasis.
银屑病对患者的生活质量有重大影响。
本研究旨在评估银屑病临床严重程度对患者生活质量的影响，并确定银屑病相关压力对患者日常生活的影响。
本横断面研究在贝尔格莱德塞尔维亚临床中心皮肤性病研究所进行。研究纳入了201例年龄在18 - 70岁之间、诊断为银屑病的患者（124名男性和77名女性），这些患者在2009年期间住院或门诊治疗。采用银屑病残疾指数（PDI）评估患者的生活质量。用银屑病生活压力量表（PLSI）测量与银屑病相关的压力，用银屑病面积和严重程度指数（PASI）评估疾病严重程度。
我们发现PLSI与所有PDI子量表及总分之间存在中度相关性（相关系数范围为0.334至0.521）。PASI与PDI子量表之间的相关性较弱，而我们未发现PASI与PLSI之间有任何显著相关性。多元回归分析结果表明，压力、更严重的疾病以及较低的教育水平是银屑病患者生活质量较差的重要决定因素。
我们的结果支持评估银屑病患者生活质量以及压力对患者适应病情影响的重要性，并且可能对银屑病临床管理中的心理压力管理方法具有重要意义。
