Takeuchi Takashi
School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan.
Dev Growth Differ. 2014 Jun;56(5):402-9. doi: 10.1111/dgd.12134. Epub 2014 Apr 16.
The regulation of cardiomyocyte proliferation is important for heart development and regeneration. The proliferation patterns of cardiomyocytes are closely related to heart morphogenesis, size, and functions. The proliferation levels are high during early embryogenesis; however, mammalian cardiomyocytes exit the cell cycle irreversibly soon after birth. The cell cycle exit inhibits cardiac regeneration in mammals. On the other hand, cardiomyocytes of adult zebrafish and probably newts can proliferate after cardiac injury, and the hearts can be regenerated. Therefore, the ability to reproliferate determines regenerative ability. As in other cells, the relationship between proliferation and differentiation is very interesting, and is closely related to cardiac development, regeneration and homeostasis. In this review, these topics are discussed.
心肌细胞增殖的调控对心脏发育和再生至关重要。心肌细胞的增殖模式与心脏形态发生、大小及功能密切相关。在胚胎发育早期，增殖水平较高；然而，哺乳动物的心肌细胞在出生后不久便不可逆地退出细胞周期。细胞周期退出抑制了哺乳动物的心脏再生。另一方面，成年斑马鱼以及蝾螈的心肌细胞在心脏损伤后能够增殖，心脏也能够再生。因此，重新增殖的能力决定了再生能力。与其他细胞一样，增殖与分化之间的关系非常有趣，且与心脏发育、再生及内稳态密切相关。在本综述中，将对这些主题进行讨论。
