Department of Biochemistry and Molecular Biology, Beijing Normal University , Gene Engineering and Biotechnology Beijing Key Laboratory, Beijing 100875, People's Republic of China.
J Agric Food Chem. 2014 May 7;62(18):4127-34. doi: 10.1021/jf405790q. Epub 2014 Apr 24.
Isogarcinol is a natural compound that we extracted from Garcinia mangostana L., and we were the first to report that it is a new immunosuppressant. In the present study, we investigated the immune regulation and anti-inflammatory effects of isogarcinol on collagen-induced arthritis (CIA) and explored its potential mechanism in the treatment of rheumatoid arthritis. The oral administration of isogarcinol significantly reduced clinical scores, alleviated cartilage and bone erosion, and reduced the levels of serum inflammatory cytokines in CIA mice. Isogarcinol inhibited xylene-induced mouse ear edema in vivo. In vitro, isogarcinol decreased iNOS and COX-2 mRNA expression and NO content by inhibiting NF-κB expression. Furthermore, isogarcinol decreased the activity of NFAT and inhibited IL-2 expression. The mechanism of action of isogarcinol is associated with down-regulation of both autoimmune and inflammatory reactions.
异芒果醇是一种从藤黄属植物中提取的天然化合物，我们首次报道其为一种新型免疫抑制剂。在本研究中，我们研究了异芒果醇对胶原诱导性关节炎（CIA）的免疫调节和抗炎作用，并探讨了其在治疗类风湿关节炎中的潜在机制。异芒果醇的口服给药显著降低了 CIA 小鼠的临床评分，减轻了软骨和骨侵蚀，并降低了血清炎症细胞因子的水平。异芒果醇抑制了二甲苯诱导的小鼠耳肿胀。在体外，异芒果醇通过抑制 NF-κB 的表达，降低了 iNOS 和 COX-2 mRNA 表达和 NO 含量。此外，异芒果醇降低了 NFAT 的活性并抑制了 IL-2 的表达。异芒果醇的作用机制与下调自身免疫和炎症反应有关。
