Wang Mengqi, Xie Yufei, Zhong Youxiu, Cen Juren, Wang Lei, Liu Yuanyuan, Zhu Ying, Tong Li, Wei Qun
Gene Engineering and Biotechnology Beijing Key Laboratory, Department of Biochemistry and Molecular Biology, Beijing Normal University , Beijing 100875, People's Republic of China.
National Vaccine and Serum Institute, Beijing 100024, People's Republic of China.
J Agric Food Chem. 2016 Nov 30;64(47):9012-9021. doi: 10.1021/acs.jafc.6b04145. Epub 2016 Nov 16.
Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice. The percentages of Th cells and macrophages were also strongly reduced. Isogarcinol appeared to act by inhibiting T helper (Th) 1 and Th17 cell differentiation via the janus kinase/signal transducers and activators of transcription pathway and by impairing macrophage function. Our data suggest that isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.
异藤黄醇是我们实验室从山竹中提取的一种新型天然免疫抑制剂。目前对于其对可治疗疾病的作用及其作用机制的了解仍然非常有限。在本研究中，我们探究了异藤黄醇在实验性自身免疫性脑脊髓炎（EAE）（一种多发性硬化症（MS）的小鼠模型）中的治疗效果。口服100 mg/kg异藤黄醇治疗显著改善了EAE小鼠的临床评分，减轻了脊髓炎症和脱髓鞘，并减少了颅内病变。Th细胞和巨噬细胞的百分比也显著降低。异藤黄醇似乎通过Janus激酶/信号转导子和转录激活子途径抑制辅助性T（Th）1和Th17细胞分化以及损害巨噬细胞功能来发挥作用。我们的数据表明，异藤黄醇有潜力成为一种治疗MS和其他自身免疫性疾病的低毒性有效治疗剂。
