Warpe Bhushan M, Poflee Sandhya V, Pande Nandu P, Shrikhande Anuradha V
Department of Pathology, IGGMC, Nagpur, Maharashtra, India.
Indian J Pathol Microbiol. 2014 Jan-Mar;57(1):69-71. doi: 10.4103/0377-4929.130902.
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis is an infectious disease that continues to be a significant health problem in a developing country like India. The cause of peripheral neuropathy associated with tuberculosis is controversial. Possibilities include the toxic effects of anti-tuberculous chemotherapy (especially, rifampicin, streptomycin & ethambutol), immune mediated neuropathy, direct invasion of nerves, vasculitic neuropathy, compressive neuropathy, and meningitic reaction. This report describes an unusual finding of tuberculous granulomas in the peripheral nerve (Greater auricular nerve) of a patient ,who presented with a painful neck swelling. Granulomas were present in Greater auricular nerve (C2,C3) biopsy specimen associated with tuberculous peri-neuritis, but with no more specific indications of the mechanism of the neuropathy.
结核病(TB)是由结核分枝杆菌引起的一种传染病,在印度这样的发展中国家仍然是一个严重的健康问题。与结核病相关的周围神经病变的病因存在争议。可能的原因包括抗结核化疗的毒性作用(特别是利福平、链霉素和乙胺丁醇)、免疫介导的神经病变、神经的直接侵犯、血管炎性神经病变、压迫性神经病变和脑膜炎反应。本报告描述了一名患者周围神经(耳大神经)出现结核性肉芽肿这一不寻常的发现,该患者表现为颈部疼痛性肿胀。耳大神经(C2、C3)活检标本中存在肉芽肿,伴有结核性神经炎,但对于神经病变的机制没有更具体的指征。