Huang Chi-Chang, Chen Yi-Ming, Kan Nai-Wen, Chao Hui-Ling, Ho Chin-Shan, Hsu Mei-Chich
Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Graduate Institute of Athletics and Coaching Science, College of Sports and Athletics, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Molecules. 2014 Apr 15;19(4):4669-80. doi: 10.3390/molecules19044669.
Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n=8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.
鹿角霜是一种著名的用于传统中药的壮阳药，具有养血、补气以及强筋健骨等多种生物活性。然而，关于鹿角霜对运动表现和身体疲劳影响的证据有限。我们评估了鹿角霜乙醇提取物在生理挑战后对提高运动能力和抗疲劳功能的潜在有益作用。将四组雄性ICR小鼠（每组n = 8）分别以0、2054和4108 mg/kg/天的剂量口服给予鹿角霜14天，分别指定为溶剂对照组、鹿角霜1倍剂量组和鹿角霜2倍剂量组。在进行15分钟游泳运动后，使用前肢握力和力竭游泳时间以及血清乳酸、氨、葡萄糖和肌酸激酶水平评估身体性能和抗疲劳功能。结果表明，补充鹿角霜1倍剂量显著提高了握力；降低了与疲劳相关的生化指标，包括乳酸和氨水平；并改善了急性运动挑战引起的骨骼肌损伤。趋势分析显示，在健康小鼠中，补充鹿角霜显著增加了握力，并剂量依赖性地降低了血清碱性磷酸酶、尿酸、甘油三酯和葡萄糖水平。因此，鹿角霜是一种具有抗疲劳药理作用的潜在药物。
