Yoo Jihee, Kim Changhee, Lee Hyerin, Ko Bong Soo, Lee Dong-Woo, Hwang Jae-Kwan
Department of Bioindustrial Engineering, Yonsei University, Seoul, Republic of Korea.
Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
Food Sci Biotechnol. 2024 Jun 13;33(15):3617-3628. doi: 10.1007/s10068-024-01606-z. eCollection 2024 Dec.
Muscle atrophy or muscle wasting, which is featured by reduced muscle function and mass, typically results from disuse, aging, and chronic diseases. The deer antler, which refers to the young and non-ossified antlers of various species of deer-related animals, is not fully calcified and comprises of densely growing hair. Here, we investigated whether -fermented antler extract (FAE) inhibits immobilization-induced muscle atrophy in C57BL/6J mice. Oral administration of FAE increased grip strength, exercise performance, muscle mass, and volume in mice. FAE stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, enhancing the mammalian target of rapamycin pathway for muscle synthesis. FAE phosphorylated Forkhead box O3 and downregulated muscle RING finger-1 and atrogin-1 for proteolysis. FAE inhibited the mRNA expression of tumor necrosis factor alpha and interleukin-6 through nuclear factor kappa B. Consequently, FAE attenuated muscle atrophy by regulating the PI3K/Akt pathway and inflammation.
肌肉萎缩或肌肉消耗，其特征是肌肉功能和质量下降，通常由废用、衰老和慢性疾病引起。鹿茸是指各种鹿科相关动物的幼嫩且未骨化的鹿角，它尚未完全钙化，由密集生长的茸毛组成。在此，我们研究了发酵鹿茸提取物（FAE）是否能抑制C57BL/6J小鼠因固定不动引起的肌肉萎缩。口服FAE可提高小鼠的握力、运动能力、肌肉质量和体积。FAE刺激磷脂酰肌醇3激酶（PI3K）/Akt通路，增强用于肌肉合成的雷帕霉素哺乳动物靶标通路。FAE使叉头框O3磷酸化，并下调肌肉环指蛋白-1和肌肉萎缩相关基因1以进行蛋白水解。FAE通过核因子κB抑制肿瘤坏死因子α和白细胞介素-6的mRNA表达。因此，FAE通过调节PI3K/Akt通路和炎症来减轻肌肉萎缩。
