Motoyama Keiichi, Tanida Yuki, Hata Kyona, Hayashi Tomoya, Higashi Taishi, Ishitsuka Yoichi, Kondo Yuki, Irie Tetsumi, Kaneko Shinichiro, Arima Hidetoshi
Graduate School of Pharmaceutical Sciences, Kumamoto University.
Chem Pharm Bull (Tokyo). 2014;62(7):636-41. doi: 10.1248/cpb.c14-00053. Epub 2014 Apr 16.
A megamolecular polysaccharide sacran was newly extracted from cyanobacterium Aphanothece sacrum. Sacran has many preferable properties for transdermal application, e.g. a safe biomaterial, a high moisturizing effect, a formation of film and hydrogel. Additionally, it was recently discovered that sacran has an anti-inflammatory effect for atopic dermatitis model mice. In this study, in order to evaluate the feasibility of sacran-hydrogel as a novel sustained release system, we prepared a sacran-hydrogel containing 4-biphenyl acetic acid (BPAA, an acidic drug), prednisolone (PD, a neutral drug) or chlorpheniramine maleate (CPM, a basic drug), and performed the in vitro release studies. The sacran-hydrogel containing BPAA, PD or CPM provided a sustained release profile in accordance with a quasi-Fickian diffusion model. Furthermore, the release rate of drugs from sacran-hydrogels can be controlled by adjusting the concentration of aluminum chloride as a cross linker. These results suggest the potential use of sacran-hydrogel as a sustained release system for drugs.
一种巨分子多糖硫酸岩藻聚糖是从蓝藻微囊藻中 newly 提取的。硫酸岩藻聚糖具有许多适合透皮应用的特性，例如一种安全的生物材料、高保湿效果、形成薄膜和水凝胶。此外，最近发现硫酸岩藻聚糖对特应性皮炎模型小鼠具有抗炎作用。在本研究中，为了评估硫酸岩藻聚糖水凝胶作为一种新型缓释系统的可行性，我们制备了含有 4-联苯乙酸（BPAA，一种酸性药物）、泼尼松龙（PD，一种中性药物）或马来酸氯苯那敏（CPM，一种碱性药物）的硫酸岩藻聚糖水凝胶，并进行了体外释放研究。含有 BPAA、PD 或 CPM 的硫酸岩藻聚糖水凝胶根据准菲克扩散模型呈现出缓释曲线。此外，通过调节作为交联剂的氯化铝浓度，可以控制药物从硫酸岩藻聚糖水凝胶中的释放速率。这些结果表明硫酸岩藻聚糖水凝胶作为药物缓释系统具有潜在的应用价值。
原文中“newly”翻译为“新地”不太准确，这里根据语境调整为“新”。
