• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

评估来源于 的多糖聚糖作为预防 HIV-1 感染的可能杀微生物剂的用途。

Evaluating the Use of Sacran, a Polysaccharide Isolated from , as a Possible Microbicide for Preventing HIV-1 Infection.

机构信息

Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.

Division of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

出版信息

Viruses. 2024 Sep 23;16(9):1501. doi: 10.3390/v16091501.

DOI:10.3390/v16091501
PMID:39339979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11437396/
Abstract

Since combination antiretroviral therapy (cART) was introduced to treat human immunodeficiency virus type-1 (HIV-1)/acquired immunodeficiency syndrome (AIDS), the AIDS mortality rate has markedly decreased, and convalescence in individuals with HIV has improved drastically. However, sexual transmission has made HIV-1 a global epidemic. Sacran is a megamolecular polysaccharide extracted from cyanobacterium that exhibits numerous desirable characteristics for transdermic applications, such as safety as a biomaterial, a high moisture retention effect, the ability to form a film and hydrogel, and an anti-inflammatory effect. In this study, we evaluated the anti-HIV-1 effects in sacran as a barrier to HIV-1 transmission. Sacran inhibited HIV-1 infection and envelope-dependent cell-to-cell fusion. Moreover, we used a Transwell assay to confirm that sacran inhibited viral diffusion and captured viruses. The synergistic effects of sacran and other anti-HIV infection drugs were also evaluated. HIV-1 infections can be reduced through the synergistic effects of sacran and anti-HIV-1 drugs. Our study suggests using sacran gel to provide protection against HIV-1 transmission.

摘要

自从联合抗逆转录病毒疗法（cART）被引入治疗人类免疫缺陷病毒 1 型（HIV-1）/获得性免疫缺陷综合征（AIDS）以来，艾滋病死亡率显著下降，HIV 感染者的康复情况也大幅改善。然而，性传播使 HIV-1 成为全球流行。沙聚糖是从蓝藻中提取的一种大型多糖，具有许多适合透皮应用的理想特性，如作为生物材料的安全性、高保湿效果、成膜和水凝胶形成能力以及抗炎作用。在这项研究中，我们评估了沙聚糖作为 HIV-1 传播屏障的抗 HIV-1 作用。沙聚糖抑制 HIV-1 感染和包膜依赖性细胞间融合。此外，我们使用 Transwell 测定法证实沙聚糖抑制病毒扩散并捕获病毒。还评估了沙聚糖与其他抗 HIV 感染药物的协同作用。沙聚糖和抗 HIV-1 药物的协同作用可降低 HIV-1 感染。我们的研究表明，使用沙聚糖凝胶可以提供针对 HIV-1 传播的保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/09aeacc4a1e6/viruses-16-01501-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/cf74167b8ff0/viruses-16-01501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/38d17f43d100/viruses-16-01501-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/0370cfc54084/viruses-16-01501-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/0ed17f8ad40c/viruses-16-01501-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/09aeacc4a1e6/viruses-16-01501-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/cf74167b8ff0/viruses-16-01501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/38d17f43d100/viruses-16-01501-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/0370cfc54084/viruses-16-01501-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/0ed17f8ad40c/viruses-16-01501-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00af/11437396/09aeacc4a1e6/viruses-16-01501-g005.jpg

相似文献

1
Evaluating the Use of Sacran, a Polysaccharide Isolated from , as a Possible Microbicide for Preventing HIV-1 Infection.评估来源于 的多糖聚糖作为预防 HIV-1 感染的可能杀微生物剂的用途。
Viruses. 2024 Sep 23;16(9):1501. doi: 10.3390/v16091501.
2
Anti-inflammatory Effects of Novel Polysaccharide Sacran Extracted from Cyanobacterium Aphanothece sacrum in Various Inflammatory Animal Models.从蓝藻囊链藻中提取的新型多糖Sacran在多种炎症动物模型中的抗炎作用
Biol Pharm Bull. 2016 Jul 1;39(7):1172-8. doi: 10.1248/bpb.b16-00208. Epub 2016 May 10.
3
The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications.巨分子多糖硫酸酯在食品和生物医学中的应用。
Molecules. 2021 Jun 2;26(11):3362. doi: 10.3390/molecules26113362.
4
Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system.巨分子多糖脱乙缩醛多糖作为水凝胶基缓释系统的潜在用途。
Chem Pharm Bull (Tokyo). 2014;62(7):636-41. doi: 10.1248/cpb.c14-00053. Epub 2014 Apr 16.
5
[Potential Use of Sacran for Dermal and Oral Preparations].[Sacran在皮肤和口腔制剂中的潜在用途]
Yakugaku Zasshi. 2019;139(3):385-391. doi: 10.1248/yakushi.18-00177-5.
6
[Anti-inflammatory Effect of Sacran on Atopic Dermatitis].[紫菜多糖对特应性皮炎的抗炎作用]
Yakugaku Zasshi. 2018;138(4):509-515. doi: 10.1248/yakushi.17-00201-4.
7
Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo.从 Aphanothece sacrum 中提取的新型多糖 sacran 对体内 2,4,6-三硝基氯苯诱导的过敏性皮炎的抗炎作用。
Ann Allergy Asthma Immunol. 2012 Feb;108(2):117-22. doi: 10.1016/j.anai.2011.10.013. Epub 2011 Nov 29.
8
[Potential Use of Sacran Hydrogels as Wound Dressing Material].[鼠李糖醛酸聚糖水凝胶作为伤口敷料材料的潜在用途]
Yakugaku Zasshi. 2018;138(4):517-520. doi: 10.1248/yakushi.17-00201-5.
9
Defensive Effects of a Unique Polysaccharide, Sacran, to Protect Keratinocytes against Extracellular Stimuli and Its Possible Mechanism of Action.一种独特的多糖——思卡恩对角质形成细胞抵御细胞外刺激的保护作用及其可能的作用机制
Biol Pharm Bull. 2018;41(10):1554-1560. doi: 10.1248/bpb.b18-00194.
10
[Industrial and Medical Material Applications of a Mega-polysaccharide Derived from Cyanobacteria].[一种源自蓝细菌的巨型多糖在工业和医学材料中的应用]
Yakugaku Zasshi. 2019;139(3):363-369. doi: 10.1248/yakushi.18-00177-2.

本文引用的文献

1
How could HIV-1 drug resistance impact preexposure prophylaxis for HIV prevention?HIV-1 耐药性如何影响 HIV 预防的暴露前预防？
Curr Opin HIV AIDS. 2022 Jul 1;17(4):213-221. doi: 10.1097/COH.0000000000000746.
2
The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications.巨分子多糖硫酸酯在食品和生物医学中的应用。
Molecules. 2021 Jun 2;26(11):3362. doi: 10.3390/molecules26113362.
3
Effectiveness of vaginal microbicides in preventing HIV transmission.阴道杀微生物剂预防 HIV 传播的效果。
Trop Med Int Health. 2020 Jul;25(7):790-802. doi: 10.1111/tmi.13401. Epub 2020 May 13.
4
Tenofovir-based preexposure prophylaxis for HIV infection among African women.基于替诺福韦的暴露前预防用于非洲女性的HIV感染
N Engl J Med. 2015 Feb 5;372(6):509-18. doi: 10.1056/NEJMoa1402269.
5
Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity.三环香豆素GUT-70通过改变膜流动性抑制HIV-1进入。
Biochem Biophys Res Commun. 2015 Feb 13;457(3):288-94. doi: 10.1016/j.bbrc.2014.12.102. Epub 2015 Jan 7.
6
Efficacy of Tenofovir 1% Vaginal Gel in Reducing the Risk of HIV-1 and HSV-2 Infection.1%替诺福韦阴道凝胶在降低HIV-1和HSV-2感染风险方面的疗效。
Clin Med Insights Womens Health. 2014 Feb 13;7:1-8. doi: 10.4137/CMWH.S10353. eCollection 2014.
7
Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system.巨分子多糖脱乙缩醛多糖作为水凝胶基缓释系统的潜在用途。
Chem Pharm Bull (Tokyo). 2014;62(7):636-41. doi: 10.1248/cpb.c14-00053. Epub 2014 Apr 16.
8
Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity.胡椒乙胺通过改变细胞膜流动性抑制 HIV-1 细胞间传播和游离感染。
Bioorg Med Chem Lett. 2014 May 1;24(9):2115-7. doi: 10.1016/j.bmcl.2014.03.041. Epub 2014 Mar 22.
9
Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo.从 Aphanothece sacrum 中提取的新型多糖 sacran 对体内 2,4,6-三硝基氯苯诱导的过敏性皮炎的抗炎作用。
Ann Allergy Asthma Immunol. 2012 Feb;108(2):117-22. doi: 10.1016/j.anai.2011.10.013. Epub 2011 Nov 29.
10
The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.鉴定一种能降低 HIV-1 Nef 介导的病毒感染力增强的小分子化合物。
PLoS One. 2011;6(11):e27696. doi: 10.1371/journal.pone.0027696. Epub 2011 Nov 15.