Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjajaran, Sumedang 45363, Indonesia.
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjajaran, Sumedang 45363, Indonesia.
Molecules. 2021 Jun 2;26(11):3362. doi: 10.3390/molecules26113362.
Natural polymer is a frequently used polymer in various food applications and pharmaceutical formulations due to its benefits and its biocompatibility compared to synthetic polymers. One of the natural polymer groups (i.e., polysaccharide) does not only function as an additive in pharmaceutical preparations, but also as an active ingredient with pharmacological effects. In addition, several natural polymers offer potential distinct applications in gene delivery and genetic engineering. However, some of these polymers have drawbacks, such as their lack of water retention and elasticity. Sacran, one of the high-molecular-weight natural polysaccharides (megamolecular polysaccharides) derived from (), has good water retention and elasticity. Historically, sacran has been used as a dietary food. Moreover, sacran can be applied in biomedical fields as an active material, excipient, and genetic engineering material. This article discusses the characteristics, extraction, isolation procedures, and the use of sacran in food and biomedical applications.
天然聚合物由于其优势以及与合成聚合物相比的生物相容性,常用于各种食品应用和药物制剂中。天然聚合物组之一(即多糖)不仅在药物制剂中作为添加剂,而且作为具有药理作用的活性成分。此外,几种天然聚合物在基因传递和基因工程中有潜在的独特应用。然而,其中一些聚合物存在缺点,例如缺乏保水性和弹性。壳聚糖是一种源自()的高分子量天然多糖(大分子多糖)之一,具有良好的保水性和弹性。从历史上看,壳聚糖一直被用作膳食食品。此外,壳聚糖可用作生物医学领域的活性物质、赋形剂和基因工程材料。本文讨论了壳聚糖的特性、提取、分离程序以及在食品和生物医学应用中的用途。