Bauer J, Gareis M, Bott A, Gedek B
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, University of Munich, F.R.G.
J Med Vet Mycol. 1989;27(1):45-50. doi: 10.1080/02681218980000061.
A bovine udder infected with Aspergillus fumigatus was analysed by physico-chemical methods (thin layer chromatography, high performance liquid chromatography and direct exposure probe-mass spectrometry) for the presence of mycotoxins. Gliotoxin, a fungal metabolite with cytotoxic and immunosuppressive properties was isolated for the first time from naturally infected tissue. The gliotoxin concentration analysed (9.2 mg kg-1 udder) was approximately 100 times higher than the concentration known to produce morphological changes of cells. Gliotoxin may play an important role in the establishment and development of an infection with A fumigatus.
对一个感染烟曲霉的牛乳房进行了物理化学方法（薄层色谱法、高效液相色谱法和直接暴露探针质谱法）分析，以检测霉菌毒素的存在。首次从自然感染组织中分离出具有细胞毒性和免疫抑制特性的真菌代谢产物——gliotoxin。分析得到的gliotoxin浓度（9.2毫克/千克乳房）比已知会引起细胞形态变化的浓度高出约100倍。Gliotoxin可能在烟曲霉感染的发生和发展中起重要作用。
