哺乳动物卵巢的发育。
Development of mammalian ovary.
机构信息
AgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, AustraliaAgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
AgResearch InvermayPuddle Alley, Mosgiel 9053, New ZealandDepartment of AnatomyUniversity of Otago, Dunedin 9054, New ZealandDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, AustraliaRobinson Research InstituteDiscipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia.
出版信息
J Endocrinol. 2014 Jun;221(3):R145-61. doi: 10.1530/JOE-14-0062. Epub 2014 Apr 16.
Pre-natal and early post-natal ovarian development has become a field of increasing importance over recent years. The full effects of perturbations of ovarian development on adult fertility, through environmental changes or genetic anomalies, are only now being truly appreciated. Mitigation of these perturbations requires an understanding of the processes involved in the development of the ovary. Herein, we review some recent findings from mice, sheep, and cattle on the key events involved in ovarian development. We discuss the key process of germ cell migration, ovigerous cord formation, meiosis, and follicle formation and activation. We also review the key contributions of mesonephric cells to ovarian development and propose roles for these cells. Finally, we discuss polycystic ovary syndrome, premature ovarian failure, and pre-natal undernutrition; three key areas in which perturbations to ovarian development appear to have major effects on post-natal fertility.
近年来，产前和产后早期卵巢发育已成为一个日益重要的领域。只有现在才真正认识到，环境变化或遗传异常对卵巢发育的干扰对成年生育能力的全部影响。要减轻这些干扰，就需要了解卵巢发育过程中涉及的各种过程。在此，我们回顾了来自老鼠、绵羊和牛的一些关于卵巢发育所涉及的关键事件的最新发现。我们讨论了生殖细胞迁移、卵黄囊形成、减数分裂和卵泡形成与激活的关键过程。我们还回顾了中肾细胞对卵巢发育的关键贡献，并提出了这些细胞的作用。最后，我们讨论了多囊卵巢综合征、卵巢早衰和产前营养不良；这三个关键领域的卵巢发育干扰似乎对产后生育能力有重大影响。
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