Nguyen Nam P, Jang Siyoung, Vock Jacqueline, Vinh-Hung Vincent, Chi Alexander, Vos Paul, Pugh Judith, Vo Richard A, Ceizyk Misty, Desai Anand, Smith-Raymond Lexie
Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N,W,, Room 2055, Washington, DC 20060, USA.
BMC Cancer. 2014 Apr 17;14:265. doi: 10.1186/1471-2407-14-265.
In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.
A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).
At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.
IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
本研究评估了调强放疗（IMRT）和基于断层放疗的图像引导放疗（IGRT）用于局部晚期食管癌的可行性。
对10例接受同步化疗的局部晚期食管癌患者进行回顾性研究，其中1例接受IMRT，9例接受IGRT。大体肿瘤体积接受的中位剂量为70 Gy（62.4 - 75 Gy）。
中位随访14个月（1 - 39个月）时，3例患者出现局部复发，6例患者出现远处转移，2例患者出现并发症（1例气管食管瘘，1例食管狭窄需反复扩张）。无患者发生3 - 4级肺炎或心脏并发症。
IMRT和IGRT治疗局部晚期食管癌可能有效，且并发症可接受。
