Xu Q, Zhang Z, Liao W, Xiang L, Yang F, Wang Z, Chen G, Tan Q, Jiao Q, Lu G
From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.).
From the Departments of Medical Imaging (Q.X., Z.Z., W.L., L.X., Q.J., G.L.)
AJNR Am J Neuroradiol. 2014 Sep;35(9):1746-52. doi: 10.3174/ajnr.A3934. Epub 2014 Apr 17.
Voxel-mirrored intrinsic functional connectivity allows the depiction of interhemispheric homotopic connections in the human brain, whereas time-shift intrinsic functional connectivity allows the detection of the extent of brain injury by measuring hemodynamic properties. We combined time-shift voxel-mirrored homotopic connectivity analyses to investigate the alterations in homotopic connectivity in mesial temporal lobe epilepsy and assessed the value of applying this approach to epilepsy lateralization and the prediction of surgical outcomes in mesial temporal lobe epilepsy.
Resting-state functional MR imaging data were acquired from patients with unilateral mesial temporal lobe epilepsy (n=62) (31 left- and 31 right-side) and healthy controls (n=33). Dynamic interhemispheric homotopic architecture seeding from each hemisphere was individually calculated by 0, 1, 2, and 3 repetition time time-shift voxel-mirrored homotopic connectivity. Voxel-mirrored homotopic connectivity maps were compared between the patient and control groups by using 1-way ANOVA for each time-shift condition, separately. Group comparisons were further performed on the laterality of voxel-mirrored homotopic connectivity in each time-shift condition. Finally, we correlated the interhemispheric homotopic connection to the surgical outcomes in a portion of the patients (n=20).
The patients with mesial temporal lobe epilepsy showed decreased homotopic connectivity in the mesial temporal structures, temporal pole, and striatum. Alterations of the bihemispheric homotopic connectivity were lateralized along with delays in the time-shift in mesial temporal lobe epilepsy. The patients with unsuccessful surgical outcomes presented larger interhemispheric voxel-mirrored homotopic connectivity differences.
This study showed whole patterns of dynamic alterations of interhemispheric homotopic connectivity in mesial temporal lobe epilepsy, extending the knowledge of abnormalities in interhemispheric connectivity in this condition. Time-shift voxel-mirrored homotopic connectivity has the potential for lateralization of unilateral mesial temporal lobe epilepsy and may have the capability of predicting surgical outcomes in this condition.
体素镜像内在功能连接可描绘人类大脑半球间的同位连接，而时移内在功能连接可通过测量血流动力学特性来检测脑损伤程度。我们结合时移体素镜像同位连接分析，以研究内侧颞叶癫痫同位连接的改变，并评估将该方法应用于内侧颞叶癫痫的定侧及手术结果预测的价值。
采集了单侧内侧颞叶癫痫患者（n = 62）（左侧31例，右侧31例）及健康对照者（n = 33）的静息态功能磁共振成像数据。通过0、1、2和3个重复时间的时移体素镜像同位连接，分别从每个半球计算动态半球间同位结构种子点。在每个时移条件下，使用单因素方差分析分别比较患者组和对照组的体素镜像同位连接图。在每个时移条件下，进一步对体素镜像同位连接的定侧进行组间比较。最后，我们将部分患者（n = 20）的半球间同位连接与手术结果进行了相关性分析。
内侧颞叶癫痫患者在内侧颞叶结构、颞极和纹状体中显示同位连接减少。双侧同位连接的改变随着内侧颞叶癫痫时移延迟而呈定侧化。手术结果不佳的患者半球间体素镜像同位连接差异更大。
本研究显示了内侧颞叶癫痫半球间同位连接动态改变的整体模式，扩展了对这种情况下半球间连接异常的认识。时移体素镜像同位连接具有对单侧内侧颞叶癫痫进行定侧的潜力，并且可能具有预测这种情况下手术结果的能力。
