The Laboratory for Tissue Engineering and Regenerative Medicine, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Nanoscale. 2014 Aug 21;6(16):9410-4. doi: 10.1039/c4nr00300d.
Coiled perimysial fibers within the heart muscle provide it with the ability to contract and relax efficiently. Here, we report on a new nanocomposite scaffold for cardiac tissue engineering, integrating coiled electrospun fibers with gold nanoparticles. Cultivation of cardiac cells within the hybrid scaffolds promoted cell organization into elongated and aligned tissues generating a strong contraction force, high contraction rate and low excitation threshold.
心肌中的螺旋状肌周纤维使心脏具有高效收缩和舒张的能力。在此，我们报告了一种新的用于心脏组织工程的纳米复合支架，该支架将螺旋状电纺纤维与金纳米颗粒结合在一起。在混合支架内培养心脏细胞可促进细胞组织为长而排列整齐的组织，从而产生强大的收缩力、高收缩率和低激发阈值。
