Frauscher Birgit, Gabelia David, Mitterling Thomas, Biermayr Marlene, Bregler Deborah, Ehrmann Laura, Ulmer Hanno, Högl Birgit
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Institute of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
Sleep. 2014 Apr 1;37(4):763-73, 773A-773B. doi: 10.5665/sleep.3586.
Many sleep disorders are characterized by increased motor activity during sleep. In contrast, studies on motor activity during physiological sleep are largely lacking. We quantitatively investigated a large range of motor phenomena during polysomnography in physiological sleep.
Prospective polysomnographic investigation.
Academic referral sleep laboratory.
One hundred healthy sleepers age 19-77 y were strictly selected from a representative population sample by a two-step screening procedure.
N/A.
Polysomnography according to American Academy of Sleep Medicine (AASM) standards was performed, and quantitative normative values were established for periodic limb movements in sleep (PLMS), high frequency leg movements (HFLM), fragmentary myoclonus (FM), neck myoclonus (NM), and rapid eye movement (REM)-related electromyographic (EMG) activity. Thirty-six subjects had a PLMS index > 5/h, 18 had a PLMS index > 15/h (90th percentile: 24.8/h). Thirty-three subjects had HFLM (90th percentile: four sequences/night). All subjects had FM (90th percentile 143.7/h sleep). Nine subjects fulfilled AASM criteria for excessive FM. Thirty-five subjects had NM (90th percentile: 8.8/h REM sleep). For REM sleep, different EMG activity measures for the mentalis and flexor digitorum superficialis muscles were calculated: the 90th percentile for phasic mentalis EMG activity for 30-sec epochs according to AASM recommendation was 15.6%, and for tonic mentalis EMG activity 2.6%. Twenty-five subjects exceeded the recently proposed phasic mentalis cutoff of 11%. None of the subjects exceeded the tonic mentalis cutoff of 9.6%.
Quantification of motor phenomena is a basic prerequisite to develop normative values, and is a first step toward a more precise description of the various motor phenomena present during sleep. Because rates of motor events were unexpectedly high even in physiological sleep, the future use of normative values for both research and clinical routine is essential.
许多睡眠障碍的特征是睡眠期间运动活动增加。相比之下，关于生理性睡眠期间运动活动的研究在很大程度上是缺乏的。我们在生理性睡眠的多导睡眠图检查中对多种运动现象进行了定量研究。
前瞻性多导睡眠图调查。
学术转诊睡眠实验室。
通过两步筛选程序从具有代表性的人群样本中严格挑选出100名年龄在19 - 77岁的健康睡眠者。
无。
按照美国睡眠医学学会（AASM）标准进行多导睡眠图检查，并为睡眠期周期性肢体运动（PLMS）、高频腿部运动（HFLM）、片段性肌阵挛（FM）、颈部肌阵挛（NM）以及快速眼动（REM）相关肌电图（EMG）活动建立了定量正常值。36名受试者的PLMS指数>5次/小时，18名受试者的PLMS指数>15次/小时（第90百分位数：24.8次/小时）。33名受试者有HFLM（第90百分位数：4次序列/晚）。所有受试者都有FM（第90百分位数143.7次/小时睡眠）。9名受试者符合AASM关于过度FM的标准。35名受试者有NM（第90百分位数：8.8次/小时快速眼动睡眠）。对于快速眼动睡眠，计算了颏肌和指浅屈肌不同的肌电图活动指标：根据AASM建议，30秒时段的相位性颏肌肌电图活动第90百分位数为15.6%，紧张性颏肌肌电图活动为2.6%。25名受试者超过了最近提出的11%的相位性颏肌临界值。没有受试者超过9.6%的紧张性颏肌临界值。
对运动现象进行量化是建立正常值的基本前提，也是朝着更精确描述睡眠期间出现的各种运动现象迈出的第一步。由于即使在生理性睡眠中运动事件的发生率也出乎意料地高，因此未来在研究和临床常规中使用正常值至关重要。
