帕金森病快速眼动睡眠期运动时基底神经节的参与情况。
Basal ganglia engagement during REM sleep movements in Parkinson's disease.
作者信息
Verma Ajay K, Acosta Lenis Sergio Francisco, Aman Joshua E, Sanabria David Escobar, Wang Jing, Pearson Amy, Hill Meghan, Patriat Remi, Schrock Lauren E, Cooper Scott E, Park Michael C, Harel Noam, Howell Michael J, MacKinnon Colum D, Vitek Jerrold L, Johnson Luke A
机构信息
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
出版信息
NPJ Parkinsons Dis. 2022 Sep 12;8(1):116. doi: 10.1038/s41531-022-00382-z.
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
为了阐明基底神经节在帕金森病（PD）快速眼动睡眠运动中的作用，我们记录了4名PD患者苍白球的神经活动。与清醒运动期间常见的去同步化不同，快速眼动睡眠运动期间β振荡（13 - 35赫兹）同步；此外，高频振荡（150 - 350赫兹）在运动期间同步，与睡眠 - 觉醒状态无关。我们的结果表明基底神经节在快速眼动睡眠和清醒运动期间的参与情况不同。
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