评估出血性疾病患者口腔手术中纤维蛋白密封剂和组织粘合剂的应用。
The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders.
机构信息
Istanbul University, Faculty of Dentistry, Department of Oral Surgery and Medicine , İstanbul, Turkey.
Hospitadent Oral and Dental Health Rehabilitation Center, Oral Surgery Department, İstanbul, Turkey.
出版信息
Turk J Haematol. 2012 Mar;29(1):40-7. doi: 10.5505/tjh.2012.07769. Epub 2012 Mar 5.
OBJECTIVE
The aim of this study was to evaluate the efficiency of two local hemostatic agents administered with apreoperative dose of replacement therapy in patients with bleeding disorders undergoing oral surgery.
MATERIAL AND METHODS
The study included 21 patients that were randomly divided into 3 groups. Patients in Group1 (n = 7) received preoperative replacement therapy and postoperative fibrin sealant applied to the surgical site. Patientsin Group 2 (n = 7) received preoperative replacement therapy and postoperative tissue adhesive applied to the surgicalsite. Patients in Group 3 (n = 7) were given replacement therapy pre- and postoperatively.
RESULTS
Postoperative bleeding was not observed in 17 of the 21 patients, including 5 in Group 1 (71.42%), 6 in Group2 (85.71%), and 6 in Group 3 (85.71%). Hemorrhagic complications occurred in only 4 of the 21 patients.
CONCLUSION
The use of fibrin sealant and tissue adhesive was beneficial, as they reduced the level of factor concentratesused for replacement therapy and resulted in rapid hemostasis at the surgical site, facilitating the ability to performserial surgical procedures concurrently.
目的
本研究旨在评估在接受口腔手术的出血性疾病患者中，术前给予替代治疗并使用两种局部止血剂的效果。
材料与方法
该研究纳入了 21 例患者，他们被随机分为 3 组。第 1 组（n=7）患者接受术前替代治疗和术后纤维蛋白密封剂应用于手术部位。第 2 组（n=7）患者接受术前替代治疗和术后组织粘合剂应用于手术部位。第 3 组（n=7）患者接受术前和术后替代治疗。
结果
21 例患者中有 17 例无术后出血，其中第 1 组 5 例（71.42%），第 2 组 6 例（85.71%），第 3 组 6 例（85.71%）。仅 4 例患者出现出血性并发症。
结论
纤维蛋白密封剂和组织粘合剂的使用是有益的，因为它们减少了用于替代治疗的因子浓缩物的使用水平，并在手术部位迅速止血，有利于同时进行连续的手术操作。
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