Mendelson Y, Kent J C
IEEE Trans Biomed Eng. 1989 Aug;36(8):844-8. doi: 10.1109/10.30810.
One of the concerns clinicians have relates to the interpretation of noninvasive pulse oximeters in newborns since at birth high levels of fetal hemoglobin (HbF) is present in the blood. Accurate in vivo studies of pulse oximeters in infants with predominantly HbF cannot be easily performed. Therefore, the objective of this in vitro study was to determine whether the presence of high levels of HbF in the blood can significantly affect the accuracy of noninvasive pulse oximeters. It is evident from our results that there is no perceptible difference in the 650-1000 nm wavelength region, which is commonly used in pulse oximetry, between the optical absorption spectra of hemolyzed whole adult and fetal blood. Our observations are in good agreement with in vivo studies published by other investigators showing considerable correlations between SpO2 measured by a pulse oximeter and SaO2 values analyzed in vitro by an IL 282 CO-Oximeter.
临床医生关注的问题之一涉及新生儿无创脉搏血氧仪的解读，因为出生时血液中存在高水平的胎儿血红蛋白（HbF）。对主要为HbF的婴儿进行脉搏血氧仪的准确体内研究不易进行。因此，这项体外研究的目的是确定血液中高水平的HbF是否会显著影响无创脉搏血氧仪的准确性。从我们的结果可以明显看出，在脉搏血氧测定中常用的650 - 1000纳米波长区域，溶血的成人全血和胎儿血的光吸收光谱之间没有明显差异。我们的观察结果与其他研究者发表的体内研究结果高度一致，这些研究表明脉搏血氧仪测量的SpO2与IL 282型血气分析仪体外分析的SaO2值之间存在显著相关性。
