Bojar Iwona, Raczkiewicz Dorota, Wdowiak Artur, Owoc Alfred
Ginekol Pol. 2014 Feb;85(2):131-9. doi: 10.17772/gp/1703.
The objective of the study was to analyze a possible association between cognitive functions and level of prolactin in menopausal women with different polymorphisms of apolipoprotein E gene (APOE). The examined population included women from the south-eastern part of Poland; aged 50-65 years; at least 2 years after their last menstruation; in good health; with at least primary education, FSH > 30 mIU/ml. The MoCA test (Montreal Cognitive Assessment Test) allowed us to exclude women with signs of dementia. The cognitive functions assessment was conducted with the CNS-VitalSigns diagnostic equipment (Polish version). The prolactin designations were conducted by SYNEVO--an accredited laboratory. The examination of APOE polymorphism was performed using the multiplex-PCR method. The results were statistically analyzed.
Higher level of prolactin turned out to be associated with better test results in the following areas: NCI, memory verbal memory psychomotor speed and concentration. Women with higher level of prolactin had better results in NCI, psychomotor speed and verbal memory tests. The test results of other cognitive function were not unequivocally related to higher levels of prolactin. Thus, it was not possible to conclude that the presence of APOE polymorphism is related to the effect of prolactin on cognitive functions of the examined menopausal women.
本研究的目的是分析载脂蛋白E基因（APOE）具有不同多态性的绝经后女性认知功能与催乳素水平之间的可能关联。研究对象包括来自波兰东南部的女性；年龄在50 - 65岁之间；最后一次月经至少2年后；身体健康；至少接受过小学教育，促卵泡激素（FSH）> 30 mIU/ml。蒙特利尔认知评估测试（MoCA）使我们能够排除有痴呆迹象的女性。认知功能评估使用CNS - VitalSigns诊断设备（波兰语版本）进行。催乳素测定由经认可的实验室SYNEVO进行。APOE多态性检测采用多重聚合酶链反应方法。对结果进行统计学分析。
结果表明，较高的催乳素水平与以下方面更好的测试结果相关：神经认知指数（NCI）、记忆、言语记忆、心理运动速度和注意力。催乳素水平较高的女性在NCI、心理运动速度和言语记忆测试中成绩更好。其他认知功能的测试结果与较高的催乳素水平并无明确关联。因此，无法得出APOE多态性的存在与催乳素对所研究的绝经后女性认知功能的影响有关的结论。
