Landini Linda
Turku PET Centre, Turku University Hospital, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Curr Pharm Des. 2014;20(39):6078-88. doi: 10.2174/1381612820666140417094458.
Cardiovascular risk factors, irregardless of their assessment modalities, are based on cardiovascular health. Lifestyle influences metabolic profiles and these changes affect cardiovascular risk factors. Cardiovascular risk factors can be classified into three basic categories: 1. Predisposing risk factors (e.g., age, gender, medical history, and genetic factors); 2. Clinical and metabolic factors (e.g., hypertension, changes in lipid metabolism, diabetes mellitus, obesity, metabolic syndrome, homocysteine, serum uric acid concetntrations, and L-arginine dimethylated derivatives); 3. Modifying behavioral factors (e.g., cigarette smoking, high caloric diet, alcohol intake, sedentary life). Some of these factors are metabolic components of body metabolism because they act by metabolic reactions while others characterized by structural alterations of the cardiovascular system, at least initially, exert their harmful effects by metabolic substrates. Metabolic responses such as biochemical substances, drugs or others, that act initially as cardiovascular risk factors, identify that an early treatment of the altered parameters observed should be a useful approach to reduce the rate of heart attacks with a significant improvement in the outcome of cardiovascular disease.
心血管危险因素,无论其评估方式如何,都基于心血管健康。生活方式影响代谢状况,而这些变化会影响心血管危险因素。心血管危险因素可分为三大类:1. 易患危险因素(如年龄、性别、病史和遗传因素);2. 临床和代谢因素(如高血压、脂质代谢变化、糖尿病、肥胖、代谢综合征、同型半胱氨酸、血清尿酸浓度和L-精氨酸二甲基化衍生物);3. 可改变的行为因素(如吸烟、高热量饮食、饮酒、久坐不动的生活方式)。其中一些因素是身体代谢的代谢成分,因为它们通过代谢反应起作用,而其他一些因素至少在最初以心血管系统的结构改变为特征,通过代谢底物发挥其有害作用。最初作为心血管危险因素起作用的代谢反应,如生化物质、药物或其他物质,表明对观察到的参数改变进行早期治疗应该是一种有用的方法,可降低心脏病发作率,并显著改善心血管疾病的预后。