Biomedical Polymers Laboratory & Jiangsu Key Laboratory of Advanced Functional Polymer Design & Application, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
Nanomedicine (Lond). 2014 Mar;9(3):487-99. doi: 10.2217/nnm.13.212.
Doxorubicin is a potent chemotherapeutic drug applied in the clinics for the treatment of various human cancers. It is typically administered as the hydrochloride salt or in liposomal forms, which are plagued with severe side effects. In recent years, pH-sensitive polymeric nanoparticles that are capable of retaining drug during circulation while actively releasing it at the tumor site and/or inside the target tumor cells have received an overwhelming interest for tumor-targeting cancer chemotherapy. This smart delivery approach has shown to elegantly resolve the in vivo stability versus intracellular drug release dilemma, as well as stealth versus tumor cell uptake dilemma. In this review, the concept and exciting new advances in pH-sensitive polymeric nanoparticles for doxorubicin delivery are presented and discussed.
多柔比星是一种有效的化疗药物，临床上用于治疗多种人类癌症。它通常以盐酸盐或脂质体的形式给药，但这些形式存在严重的副作用。近年来，具有 pH 敏感性的聚合物纳米粒子在循环过程中能够保留药物，而在肿瘤部位和/或靶肿瘤细胞内主动释放药物，受到了用于肿瘤靶向癌症化疗的广泛关注。这种智能递药方法巧妙地解决了体内稳定性与细胞内药物释放之间的矛盾，以及隐形与肿瘤细胞摄取之间的矛盾。本文综述了用于多柔比星递送的 pH 敏感性聚合物纳米粒子的概念和令人兴奋的新进展，并进行了讨论。
