麻叶千里光介导的氧化铜纳米粒子的生物合成与表征及其抗菌和抗癌活性评价。
Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity.
机构信息
School of Science and Engineering, Teesside University, Middlesbrough - TS1 3BA, Tees Valley, UK; Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore 641 021, Tamil Nadu, India.
School of Science and Engineering, Teesside University, Middlesbrough - TS1 3BA, Tees Valley, UK.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14;129:255-8. doi: 10.1016/j.saa.2014.03.027. Epub 2014 Mar 28.
Copper oxide nanoparticles were synthesized by biological method using aqueous extract of Acalypha indica leaf and characterized by UV-visible spectroscopy, XRD, FT-IR, SEM TEM and EDX analysis. The synthesised particles were highly stable, spherical and particle size was in the range of 26-30 nm. The antimicrobial activity of A.indica mediated copper oxide nanoparticles was tested against selected pathogens. Copper oxide nanoparticles showed efficient antibacterial and antifungal effect against Escherichia coli, Pseudomonas fluorescens and Candida albicans. The cytotoxicity activity of A.indica mediated copper nanoparticles was evaluated by MTT assay against MCF-7 breast cancer cell lines and confirmed that copper oxide nanoparticles have cytotoxicity activity.
采用生物法，以苘麻叶的水提物为还原剂和稳定剂，制备了氧化铜纳米粒子，并采用 UV-可见光谱、XRD、FT-IR、SEM、TEM 和 EDX 分析对其进行了表征。所合成的粒子高度稳定，呈球形，粒径在 26-30nm 范围内。测试了苘麻介导的氧化铜纳米粒子对选定病原体的抗菌活性。氧化铜纳米粒子对大肠杆菌、荧光假单胞菌和白色念珠菌表现出有效的抗菌和抗真菌作用。通过 MTT 法评估了 MCF-7 乳腺癌细胞系对苘麻介导的铜纳米粒子的细胞毒性活性，证实了氧化铜纳米粒子具有细胞毒性活性。
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