Gebreslassie Yemane Tadesse, Gebremeskel Fisseha Guesh
Department of Chemistry, College of Natural and Computational Science, Adigrat University, P.O. Box 50, Adigrat, Ethiopia.
Department of Chemistry, College of Natural Sciences, Arba Minch University, P.O. Box 21, Arba Minch, Ethiopia.
Biotechnol Rep (Amst). 2024 Jan 12;41:e00828. doi: 10.1016/j.btre.2024.e00828. eCollection 2024 Mar.
Nanotechnology has made remarkable advancements in recent years, revolutionizing various scientific fields, industries, and research institutions through the utilization of metal and metal oxide nanoparticles. Among these nanoparticles, copper oxide nanoparticles (CuO NPs) have garnered significant attention due to their versatile properties and wide-range applications, particularly, as effective antimicrobial and anticancer agents. CuO NPs can be synthesized using different methods, including physical, chemical, and biological approaches. However, conventional chemical and physical approaches are expensive, resource-intensive, and involve the use of hazardous chemicals, which can pose risks to human health and the environment. In contrast, biological synthesis provides a sustainable and cost-effective alternative by eliminating chemical pollutants and allowing for the production of CuO NPs of tailored sizes and shapes. This comprehensive review focused on the green synthesis of CuO NPs using various biological resources, such as plants, microorganisms, and other biological derivatives. Current knowledge and recent trends in green synthesis methods for CuO NPs are discussed, with a specific emphasis on their biomedical applications, particularly in combating cancer and microbial infections. This review highlights the significant potential of CuO NPs in addressing these diseases. By capitalizing on the advantages of biological synthesis, such as environmental safety and the ability to customize nanoparticle characteristics, CuO NPs have emerged as promising therapeutic agents for a wide range of conditions. This review presents compelling findings, demonstrating the remarkable achievements of biologically synthesized CuO NPs as novel therapeutic agents. Their unique properties and mechanisms enable effective combating against cancer cells and various harmful microbial infections. CuO NPs exhibit potent anticancer activity through diverse mechanisms, including induction of apoptosis, inhibition of angiogenesis, and modulation of signaling pathways. Additionally, their antimicrobial activity manifests through various mechanisms, such as disrupting microbial membranes, generating reactive oxygen species, and interfering with microbial enzymes. This review offers valuable insights into the substantial potential of biologically synthesized CuO NPs as an innovative approach for future therapeutic interventions against cancer and microbial infections.
近年来，纳米技术取得了显著进展，通过利用金属和金属氧化物纳米颗粒，彻底改变了各个科学领域、行业和研究机构。在这些纳米颗粒中，氧化铜纳米颗粒（CuO NPs）因其多功能特性和广泛应用而备受关注，特别是作为有效的抗菌和抗癌剂。CuO NPs可以使用不同的方法合成，包括物理、化学和生物方法。然而，传统的化学和物理方法成本高昂、资源密集，并且涉及使用有害化学物质，这可能对人类健康和环境构成风险。相比之下，生物合成通过消除化学污染物并允许生产定制尺寸和形状的CuO NPs，提供了一种可持续且具有成本效益的替代方案。这篇综述聚焦于使用各种生物资源（如植物、微生物和其他生物衍生物）绿色合成CuO NPs。讨论了CuO NPs绿色合成方法的当前知识和最新趋势，特别强调了它们在生物医学应用中的作用，尤其是在对抗癌症和微生物感染方面。这篇综述强调了CuO NPs在解决这些疾病方面的巨大潜力。通过利用生物合成的优势，如环境安全性和定制纳米颗粒特性的能力，CuO NPs已成为治疗多种病症的有前途的治疗剂。这篇综述呈现了令人信服的研究结果，证明了生物合成的CuO NPs作为新型治疗剂的显著成就。它们独特的性质和作用机制能够有效地对抗癌细胞和各种有害的微生物感染。CuO NPs通过多种机制表现出强大的抗癌活性，包括诱导细胞凋亡、抑制血管生成和调节信号通路。此外，它们的抗菌活性通过多种机制表现出来，如破坏微生物膜、产生活性氧和干扰微生物酶。这篇综述为生物合成的CuO NPs作为未来对抗癌症和微生物感染的治疗干预创新方法的巨大潜力提供了有价值的见解。
