Devaraji Mahalakshmi, Thanikachalam Punniyakoti V, Elumalai Karthikeyan
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Biotechnol Notes. 2024 Jun 5;5:80-99. doi: 10.1016/j.biotno.2024.06.001. eCollection 2024.
Nanotechnology is a modern scientific discipline that uses nanoparticles of metals like copper, silver, gold, platinum, and zinc for various applications. Copper oxide nanoparticles (CuONPs) are effective in biomedical settings, such as killing bacteria, speeding up reactions, stopping cancer cells, and coating surfaces. These inorganic nanostructures have a longer shelf life than their organic counterparts and are chemically inert and thermally stable. However, commercial synthesis of NPs often involves harmful byproducts and hazardous chemicals. Green synthesis for CuONPs offers numerous benefits, including being clean, harmless, economical, and environmentally friendly. Using naturally occurring organisms like bacteria, yeast, fungi, algae, and plants can make CuONPs more environmentally friendly. CuONPs are expected to be used in nanomedicine due to their potent antimicrobial properties and disinfecting agents for infectious diseases. This comprehensive review looks to evaluate research articles published in the last ten years that investigate the antioxidant, anticancer, antibacterial, wound healing, dental application and catalytic properties of copper nanoparticles generated using biological processes. Utilising the scientific approach of large-scale data analytics. However, their toxic effects on vertebrates and invertebrates raise concerns about their use for diagnostic and therapeutic purposes. Therefore, biocompatibility and non-toxicity are crucial for selecting nanoparticles for clinical research.
纳米技术是一门现代科学学科,它使用铜、银、金、铂和锌等金属的纳米颗粒用于各种应用。氧化铜纳米颗粒(CuONPs)在生物医学领域很有效,例如杀死细菌、加速反应、阻止癌细胞以及涂层表面。这些无机纳米结构比它们的有机对应物具有更长的保质期,并且化学性质惰性且热稳定。然而,纳米颗粒的商业合成通常涉及有害副产物和危险化学品。CuONPs的绿色合成具有许多优点,包括清洁、无害、经济和环境友好。使用细菌、酵母、真菌、藻类和植物等天然存在的生物体可以使CuONPs更环保。由于其强大的抗菌特性,CuONPs有望用于纳米医学以及作为传染病的消毒剂。这篇综述旨在评估过去十年发表的研究文章,这些文章研究了通过生物过程生成的铜纳米颗粒的抗氧化、抗癌、抗菌、伤口愈合、牙科应用和催化特性。利用大规模数据分析的科学方法。然而,它们对脊椎动物和无脊椎动物的毒性作用引发了对其用于诊断和治疗目的的担忧。因此,生物相容性和无毒性对于选择用于临床研究的纳米颗粒至关重要。