Yao Da Lei, Zhang Chang Hao, Luo Jie, Jin Mei, Zheng Ming Shan, Cui Jiong Mo, Son Jong Keun, Li Gao
Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
Arch Pharm Res. 2015 Apr;38(4):480-4. doi: 10.1007/s12272-014-0398-1. Epub 2014 Apr 22.
Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (8-11), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.
从胡桃楸叶中分离得到两个新的二芳基庚烷类化合物（1和3）、两个已知的二芳基庚烷类化合物（2和4），以及两个四氢萘酮（5和6）、一个萘醌（7）、四个苯丙素类化合物（8 - 11）和一个酚类化合物（12）。通过光谱和化学数据对它们的结构进行了鉴定。化合物2和10首次从该植物中分离得到，化合物8和12首次从胡桃属植物中分离得到。在这些化合物中，只有7对培养的MGC - 803、A549、K562和HeLa肿瘤细胞系表现出中等细胞毒性，IC50值分别为25.90、28.60、39.06、44.90 μM。
