Saxena Beenam, Sharma Shiv
Department of Zoology, Bareilly College, Bareilly, Uttar Pradesh, India.
Toxicol Int. 2014 Jan;21(1):65-8. doi: 10.4103/0971-6580.128798.
The present study was carried out to evaluate the toxic effect of blend of some food colors on Swiss albino rats.
A blend (1:1:1) of sunset yellow, metanil yellow and tartrazine showed additive effects on serological parameters which indicate that addition of these dye together in food stuff may give rise to more toxic effects than are produced by each dye individually. Animals were divided into four groups (I, II, III, and IV). First group was treated as control and respective group of animals received 25, 50 and 75 mg/kg body weight blend of food colors by gavaging up to 30 days.
The serological study showed a decrease in total protein and albumin and an increase in alkaline phosphatase, SGPT and total bilirubin. The results revealed that oral administration of these blend did not affect the body weight gain.
The prolonged consumption of the blend may cause adverse effect on human health.
本研究旨在评估某些食用色素混合物对瑞士白化大鼠的毒性作用。
日落黄、间苯二酚黄和柠檬黄以1:1:1的比例混合，对血清学参数显示出相加效应，这表明在食品中同时添加这些染料可能比每种染料单独产生的毒性作用更大。将动物分为四组（I、II、III和IV）。第一组作为对照组，其余各组动物通过灌胃给予25、50和75mg/kg体重的食用色素混合物，持续30天。
血清学研究显示总蛋白和白蛋白减少，碱性磷酸酶、谷丙转氨酶和总胆红素增加。结果表明，口服这些混合物不会影响体重增加。
长期食用该混合物可能对人体健康产生不良影响。
