College of Korean Medicine, Semyung University, Jecheon, Korea.
Department of Oriental Medical Food and Nutrition, Semyung University, Jecheon, Korea.
J Ginseng Res. 2014 Apr;38(2):89-96. doi: 10.1016/j.jgr.2013.10.001. Epub 2013 Dec 18.
The protective effect of ginsenoside Re, isolated from ginseng berry, against acute gastric mucosal lesions was examined in rats with a single intraperitoneal injection of compound 48/80 (C48/80). Ginsenoside Re (20 mg/kg or 100 mg/kg) was orally administered 0.5 h prior to C48/80 treatment. Ginsenoside Re dose-dependently prevented gastric mucosal lesion development 3 h after C48/80 treatment. Increases in the activities of myeloperoxidase (MPO; an index of neutrophil infiltration) and xanthine oxidase (XO) and the content of thiobarbituric acid reactive substances (TBARS; an index of lipid peroxidation) and decreases in the contents of hexosamine (a marker of gastric mucus) and adherent mucus, which occurred in gastric mucosal tissues after C48/80 treatment, were significantly attenuated by ginsenoside Re. The elevation of Bax expression and the decrease in Bcl2 expression after C48/80 treatment were also attenuated by ginsenoside Re. Ginsenoside Re significantly attenuated all these changes 3 h after C48/80 treatment. These results indicate that orally administered ginsenoside Re protects against C48/80-induced acute gastric mucosal lesions in rats, possibly through its stimulatory action on gastric mucus synthesis and secretion, its inhibitory action on neutrophil infiltration, and enhanced lipid peroxidation in the gastric mucosal tissue.
从人参果中分离得到的人参皂苷 Re 对腹腔注射复合 48/80（C48/80）的大鼠急性胃黏膜损伤的保护作用进行了研究。人参皂苷 Re（20mg/kg 或 100mg/kg）在 C48/80 处理前 0.5h 口服给药。人参皂苷 Re 可剂量依赖性地预防 C48/80 处理后 3h 胃黏膜损伤的发生。C48/80 处理后胃黏膜组织中髓过氧化物酶（MPO；中性粒细胞浸润的指标）和黄嘌呤氧化酶（XO）活性的增加以及硫代巴比妥酸反应物质（TBARS；脂质过氧化的指标）含量的增加和己糖胺（胃黏液的标志物）和黏附性黏液含量的减少，均被人参皂苷 Re 显著减弱。C48/80 处理后 Bax 表达升高和 Bcl2 表达降低也被人参皂苷 Re 减弱。人参皂苷 Re 在 C48/80 处理后 3h 显著减弱了所有这些变化。这些结果表明，口服给予的人参皂苷 Re 可通过刺激胃黏液合成和分泌、抑制中性粒细胞浸润以及增强胃黏膜组织中的脂质过氧化，对 C48/80 诱导的大鼠急性胃黏膜损伤起到保护作用。
