Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Korea.
Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Korea ; Research Center, BIFIDO Co. Ltd, Kangwon, Korea.
J Ginseng Res. 2014 Apr;38(2):97-105. doi: 10.1016/j.jgr.2013.12.003. Epub 2014 Jan 9.
Understanding what causes changes in the flux of free fatty acids (FFA) is important to elucidate the etiology of metabolic syndrome. The first aim of this study was to test whether or not hormones and the autonomic nervous system influence blood FFA levels. A secondary aim was to test by means of a multiple group path analysis whether the consumption of fermented red ginseng (FRG; Panax ginseng) would influence those causal relationships.
Ninety-three postmenopausal women (age 50-73 yr) were randomly divided into two groups. One group (44 women; age, 58.4 ± 5.9 yr; body mass index, 23.6 ± 2.5 kg/m(2)) was supplied placebo capsules and the other group (49 women, age 58.4 ± 5.5 yr; body mass index, 22.9 ± 2.4 kg/m(2)) was supplied FRG capsules. Both prior to and after the study (2 wk), blood samples were collected from the participants and several blood variables were measured and analyzed.
Squared multiple correlations of FFA were 0.699 in the placebo group and 0.707 in the FRG group. The unstandardized estimate of estradiol (E2) for FFA was 0.824 in both groups.
The path coefficients of cortisol and the branchial pulse for FFA were significantly different between the FRG group and the placebo group.
了解是什么引起游离脂肪酸（FFA）通量的变化对于阐明代谢综合征的病因非常重要。本研究的首要目的是检验激素和自主神经系统是否会影响血液 FFA 水平。次要目的是通过多元分组路径分析检验发酵红参（FRG；人参）的摄入是否会影响这些因果关系。
93 名绝经后妇女（年龄 50-73 岁）被随机分为两组。一组（44 名妇女；年龄 58.4 ± 5.9 岁；体重指数 23.6 ± 2.5 kg/m²）给予安慰剂胶囊，另一组（49 名妇女，年龄 58.4 ± 5.5 岁；体重指数 22.9 ± 2.4 kg/m²）给予 FRG 胶囊。在研究前后（2 周），从参与者中采集血样，并测量和分析了几种血液变量。
安慰剂组 FFA 的平方多重相关系数为 0.699，FRG 组为 0.707。两组中雌二醇（E2）对 FFA 的未标准化估计值均为 0.824。
FRG 组和安慰剂组的皮质醇和鳃脉冲对 FFA 的路径系数有显著差异。
