Cheon Jeong-Mu, Kim Dae-Ik, Kim Kil-Soo
Department of Veterinary Toxicology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Daegu Technopark Oriental Medicine Industry Support Center, Daegu, Korea.
J Ginseng Res. 2015 Oct;39(4):331-7. doi: 10.1016/j.jgr.2015.03.005. Epub 2015 Mar 23.
The biological actions of various ginseng extracts have been studied for treating obesity and diabetes mellitus. However, few studies have evaluated the effects of fermented Korean Red Ginseng (Panax ginseng Meyer) on metabolic syndrome. The present study evaluated the antiobesity and antidiabetic effects of fermented red ginseng (FRG) on old-aged, obese, leptin-deficient (B6.V-Lepob, "ob/ob") mice.
The animals were divided into three groups and given water containing 0%, 0.5%, and 1.0% FRG for 16 wk. The effect of FRG on ob/ob mice was determined by measuring changes in body weight, levels of blood glucose, serum contents of triglycerides, total cholesterol and free fatty acids, messenger RNA (mRNA) expressions of key factors associated with insulin action, such as insulin receptor (IR), lipoprotein lipase (LPL), glucose transporter 1 and 4 (GLUT1 and GLUT4), peroxisome proliferators-activated receptor gamma (PPAR-γ), and phosphoenolpyruvate carboxykinase (PEPCK) in the liver and in muscle, and histology of the liver and pancreas.
FRG-treated mice had decreased body weight and blood glucose levels compared with control ob/ob mice. However, anti-obesity effect of FRG was not evident rather than hypoglycemic effect in old aged ob/ob mice. The hyperlipidemia in control group was attenuated in FRG-treated ob/ob mice. The mRNA expressions of IR, LPL, GLUT1, GLUT4, PPAR-γ, and PEPCK in the liver and in muscle were increased in the FRG-treated groups compared with the control group.
These results suggest that FRG may play a vital role in improving insulin sensitivity relative to reducing body weight in old-aged ob/ob mice.
已对各种人参提取物治疗肥胖症和糖尿病的生物学作用展开研究。然而，鲜有人研究发酵高丽参（人参迈耶）对代谢综合征的影响。本研究评估了发酵红参（FRG）对老年肥胖、瘦素缺乏（B6.V-Lepob，“ob/ob”）小鼠的抗肥胖和抗糖尿病作用。
将动物分为三组，给予含0%、0.5%和1.0%FRG的水，持续16周。通过测量体重变化、血糖水平、甘油三酯、总胆固醇和游离脂肪酸的血清含量、肝脏和肌肉中与胰岛素作用相关的关键因子如胰岛素受体（IR）、脂蛋白脂肪酶（LPL）、葡萄糖转运蛋白1和4（GLUT1和GLUT4）、过氧化物酶体增殖物激活受体γ（PPAR-γ）以及磷酸烯醇丙酮酸羧激酶（PEPCK）的信使核糖核酸（mRNA）表达，以及肝脏和胰腺的组织学，来确定FRG对ob/ob小鼠的影响。
与对照ob/ob小鼠相比，FRG处理的小鼠体重和血糖水平降低。然而，在老年ob/ob小鼠中，FRG的抗肥胖作用不如降血糖作用明显。FRG处理的ob/ob小鼠减轻了对照组的高脂血症。与对照组相比，FRG处理组肝脏和肌肉中IR、LPL、GLUT1、GLUT4、PPAR-γ和PEPCK的mRNA表达增加。
这些结果表明，FRG在改善老年ob/ob小鼠胰岛素敏感性而非减轻体重方面可能发挥重要作用。
