Morohoshi T, Nakamura N, Hayashi K, Kanda M
Virchows Arch A Pathol Anat Histol. 1980;387(2):125-32. doi: 10.1007/BF00430694.
A case of the lung cancer associated with marked elevation of serum (7820 IU/1) and of urinary amylase (2225 IU/1) was autopsied. Material was examined histopathologically, electronmicroscopically and biochemically. The pulmonary tumor tissues showed histological pattern of papillary adenocarcinoma. In addition to the small round bodies which were very similar to secretory granules, many large round bodies were noticed, diffusely distributed in the tumor cell. These large round bodies ranged from 0.2 to 0.7 micrometers in diameter and showed a lamellar or annular pattern. The soluble phase of the homogenized pulmonary tumor tissues had an amylase level of 11,300 IU/g of protein, which consisted of S-type isoamylase with minor components. Cholesterol, triglyceride and phospholipid were also present at greater concentration in the tumor tissue than the normal pulmonary tissue. The large round bodies appeared too, to be amylase including bodies from the electronmicroscopical and biochemical findings.
对一例伴有血清淀粉酶（7820 IU/1）和尿淀粉酶（2225 IU/1）显著升高的肺癌患者进行了尸检。对取材进行了组织病理学、电子显微镜和生物化学检查。肺肿瘤组织呈现乳头状腺癌的组织学模式。除了与分泌颗粒非常相似的小圆形体之外，还发现许多大圆形体，它们弥漫分布于肿瘤细胞中。这些大圆形体直径为0.2至0.7微米，呈现层状或环状模式。肺肿瘤组织匀浆的可溶相淀粉酶水平为11300 IU/g蛋白质，其由S型同工淀粉酶及少量其他成分组成。肿瘤组织中胆固醇、甘油三酯和磷脂的浓度也高于正常肺组织。从电子显微镜和生物化学检查结果来看，这些大圆形体似乎也是包含淀粉酶的小体。
