增强疗法不会增强大鼠深部脑刺激的抗抑郁样作用。

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

作者信息

Laver Bryce, Diwan Mustansir, Nobrega José N, Hamani Clement

机构信息

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8.

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8; Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8.

出版信息

J Affect Disord. 2014 Jun;161:87-90. doi: 10.1016/j.jad.2014.03.007. Epub 2014 Mar 15.

DOI:10.1016/j.jad.2014.03.007

PMID:24751313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5756073/

Abstract

BACKGROUND

Clinical trials have shown promising results with the use of subcallosal cingulate gyrus deep brain stimulation (DBS) for treatment-resistant depression. However, strategies to manage patients who do not respond to this therapy have not been explored in detail. In rats, DBS in the ventromedial prefrontal cortex (vmPFC) induces a significant antidepressant-like response in the forced swim test (FST). We have used this test to investigate potential interactions between DBS and clinically used augmentative regimens.

METHODS

Rats undergoing the FST were treated with vmPFC DBS along with different augmentative drugs, namely buspirone, risperidone and pindolol. Locomotor activity was tested in an open field.

RESULTS

DBS induced a significant reduction in immobility scores as compared to saline treated controls. These antidepressant-like effects, however, were not potentiated by the co-administration of buspirone, risperidone or pindolol.

LIMITATIONS

Despite having good predictive validity, animal models are limited from a translational perspective.

CONCLUSIONS

Our results indicate that that the antidepressant-like effects of vmPFC DBS in the FST are not enhanced by augmentative therapies.

摘要

背景

临床试验表明，使用扣带回下膝状回深部脑刺激（DBS）治疗难治性抑郁症取得了令人鼓舞的结果。然而，对于对这种治疗无反应的患者的管理策略尚未进行详细探讨。在大鼠中，腹内侧前额叶皮质（vmPFC）的DBS在强迫游泳试验（FST）中可诱导显著的抗抑郁样反应。我们使用该试验来研究DBS与临床使用的增效方案之间的潜在相互作用。

方法

接受FST的大鼠接受vmPFC DBS治疗，并同时使用不同的增效药物，即丁螺环酮、利培酮和吲哚洛尔。在旷场中测试运动活动。

结果

与盐水处理的对照组相比，DBS显著降低了不动时间得分。然而，丁螺环酮、利培酮或吲哚洛尔的联合使用并未增强这些抗抑郁样作用。

局限性

尽管动物模型具有良好的预测效度，但从转化的角度来看，其存在局限性。

结论

我们的结果表明，增效疗法不会增强vmPFC DBS在FST中的抗抑郁样作用。

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增强疗法不会增强大鼠深部脑刺激的抗抑郁样作用。

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

作者信息

Laver Bryce, Diwan Mustansir, Nobrega José N, Hamani Clement

机构信息

Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8.

出版信息

J Affect Disord. 2014 Jun;161:87-90. doi: 10.1016/j.jad.2014.03.007. Epub 2014 Mar 15.

DOI:10.1016/j.jad.2014.03.007

PMID:24751313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5756073/

Abstract

BACKGROUND

METHODS

Rats undergoing the FST were treated with vmPFC DBS along with different augmentative drugs, namely buspirone, risperidone and pindolol. Locomotor activity was tested in an open field.

RESULTS

LIMITATIONS

Despite having good predictive validity, animal models are limited from a translational perspective.

CONCLUSIONS

Our results indicate that that the antidepressant-like effects of vmPFC DBS in the FST are not enhanced by augmentative therapies.

摘要

背景

方法

接受FST的大鼠接受vmPFC DBS治疗，并同时使用不同的增效药物，即丁螺环酮、利培酮和吲哚洛尔。在旷场中测试运动活动。

结果

与盐水处理的对照组相比，DBS显著降低了不动时间得分。然而，丁螺环酮、利培酮或吲哚洛尔的联合使用并未增强这些抗抑郁样作用。

局限性

尽管动物模型具有良好的预测效度，但从转化的角度来看，其存在局限性。

结论

我们的结果表明，增效疗法不会增强vmPFC DBS在FST中的抗抑郁样作用。

增强疗法不会增强大鼠深部脑刺激的抗抑郁样作用。

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

LIMITATIONS

CONCLUSIONS

背景

方法

结果

局限性

结论

相似文献

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增强疗法不会增强大鼠深部脑刺激的抗抑郁样作用。

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

LIMITATIONS

CONCLUSIONS

背景

方法

结果

局限性

结论