Department of Chiropractic, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia, Australia.
PLoS One. 2022 Nov 21;17(11):e0277991. doi: 10.1371/journal.pone.0277991. eCollection 2022.
Spinal pain has been previously linked with cardiovascular disease risk factors in children. This study investigated the prospective associations between cardiovascular disease risk factors and non-traumatic spinal pain occurrences in children, and examined the moderating role of sex and health-related physical activity in these relationships.
We used prospective data from the Childhood Health, Activity, and Motor Performance School Study Denmark (CHAMPS Study-DK). The exposure variables were a clustered cardiovascular risk score and homeostasis assessment model-estimated insulin resistance (HOMA-IR) score collected in 2008 and 2010. The spinal pain outcome comprised the number of weeks of non-traumatic spinal pain from 2008-2010 and 2010-2012. Potential confounders included age, sex, and time spent in moderate-to-vigorous intensity physical activity. We constructed age-adjusted mixed negative binominal regression models to investigate the prospective associations of cardiovascular disease risk factors and non-traumatic spinal pain, while considering the potential moderating roles of sex and physical activity in these relationships.
Girls with low HOMA-IR scores and boys with low clustered cardiovascular disease risk scores, who engaged in higher levels of moderate-to-vigorous physical activity, reported more weeks of spinal pain, compared to girls with high HOMA-IR scores (p = 0.001) and boys with high clustered cardiovascular disease risk scores (p = 0.024). whereas boys with higher clustered cardiovascular disease risk who had less time in moderate-to-vigorous physical activity reported more weeks of spinal pain than boys with low clustered cardiovascular disease risk score (p = 0.024).
Our results show that cardiovascular disease risk factors are related to future occurrences of non-traumatic spinal pain. However, these relationships appear complex and dependent on the nature of the interactions with sex and physical activity.
先前的研究表明，儿童的脊柱疼痛与心血管疾病的危险因素有关。本研究旨在探讨心血管疾病危险因素与儿童非创伤性脊柱疼痛之间的前瞻性关联，并检验性别和与健康相关的体力活动在这些关系中的调节作用。
我们使用来自丹麦儿童健康、活动和运动表现研究（CHAMPS 研究-DK）的前瞻性数据。暴露变量包括 2008 年和 2010 年收集的心血管风险评分聚类和稳态模型估计的胰岛素抵抗（HOMA-IR）评分。脊柱疼痛结局包括 2008-2010 年和 2010-2012 年期间非创伤性脊柱疼痛的周数。潜在混杂因素包括年龄、性别和中等到剧烈强度体力活动的时间。我们构建了年龄调整后的混合负二项回归模型，以调查心血管疾病危险因素与非创伤性脊柱疼痛之间的前瞻性关联，并考虑了性别和体力活动在这些关系中的潜在调节作用。
与 HOMA-IR 评分较高的女孩（p=0.001）和心血管疾病风险评分较高的男孩（p=0.024）相比，HOMA-IR 评分较低的女孩和心血管疾病风险评分较低的男孩，进行更多的中等到剧烈强度体力活动，报告的脊柱疼痛周数更多。而进行较少中等到剧烈强度体力活动的心血管疾病风险评分较高的男孩报告的脊柱疼痛周数多于心血管疾病风险评分较低的男孩（p=0.024）。
我们的研究结果表明，心血管疾病危险因素与非创伤性脊柱疼痛的未来发生有关。然而，这些关系似乎很复杂，取决于与性别和体力活动相互作用的性质。
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