Hirnle P, Geppert M
Department of Gynecology and Obstetrics, University of Tübingen, West Germany.
Lymphology. 1989 Jun;22(2):100-2.
Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment). Granulomatous reaction, microabscesses, and small necrotic foci were observed. After a month, fibrosis was detectable in all lymph nodes. The damage to microscopic lymph node structures after Oil-Bleo was moderate. These findings suggest that Oil-Bleo may be useful in local treatment of lymph node metastases.
在一项犬实验中，经鼓室内注射博来霉素油悬液（油剂博来霉素）。药物在数周内以可检测到的浓度留存于淋巴结中。对这些淋巴结的组织学变化进行了检查，并与3个对照组（水剂博来霉素、碘油及未治疗组）进行了比较。观察到肉芽肿反应、微脓肿和小坏死灶。1个月后，在所有淋巴结中均检测到纤维化。油剂博来霉素对淋巴结微观结构的损害为中度。这些发现表明，油剂博来霉素可能对淋巴结转移的局部治疗有用。
